Volume : 12, Issue : 01, January – 2025

Title:

EXCIPIENT USED IN NASAL SPRAY FORMULATION
‬

Authors :

Payal Ramesh Gaikwad, Sanjana Shridhar Walwante, Nandkishor Deshmukh, Dr. Swati Deshmukh

Abstract :

Excipients in nasal spray formulations are indispensable for ensuring that the active pharmaceutical ingredients (APIs) are delivered effectively, safely, and with minimal discomfort to the patient. The nasal route is advantageous for its rapid absorption and non-invasive nature, making it an appealing option for both systemic and local drug delivery. However, the success of a nasal spray formulation largely depends on the careful selection of excipients, which serve various functions such as improving drug solubility, maintaining stability, and enhancing patient tolerability. One of the most important excipients is the solvent, with purified or sterile water being the most commonly used due to its safety and compatibility with the nasal mucosa. In certain cases, co-solvents like ethanol or propylene glycol are incorporated to dissolve poorly soluble drugs or to enhance the permeability of the nasal membrane, thereby improving drug absorption.
Buffers are another key component, as they ensure that the formulation’s pH is within a range that is compatible with the nasal environment, typically between 4.5 and 6.5. This helps prevent irritation to the sensitive nasal mucosa while also ensuring the stability of the API, as certain drugs may degrade or become ineffective outside of a specific pH range. Common buffering agents include phosphate and citrate buffers, which are selected based on their ability to maintain pH over time.
Key words: Nasal spray, excipients, buffering agent, solvent, ph,api

Cite This Article:

Please cite this article in press Payal Ramesh Gaikwad et al., Excipient Used In Nasal Spray Formulation.,Indo Am. J. P. Sci, 2025; 12 (01).

Number of Downloads : 10

References:

1. Khan, M. I., & McGinity, J. W. (2018). “Nasal Drug Delivery: A Review of Formulation Strategies.” Journal of Drug Delivery Science and Technology, 45, 143-158.
2. Patel, A. R., & Patel, V. F. (2019). “Formulation and Evaluation of Nasal Spray: A Review.” International Journal of Pharmaceutical Sciences and Research, 10(3), 944-953.
3. Bhalekar, M. R., & Ghosh, A. (2020). “Recent Trends in Nasal Drug Delivery Systems: A Review.” Pharmaceutical Technology, 44(1), 38-46.
4. Patel, R., & Varma, M. (2021). “Formulation and Evaluation of Nasal Spray: A Comprehensive Review.” Journal of Pharmaceutical Research International, 33(1), 58-70.
5. Hassan, F. H., & Rahman, M. M. (2021). “Nasal Drug Delivery: Recent Advances and Challenges.” Frontiers in Pharmacology, 12, 707214.
6. Uddin, S., & Rahman, M. A. (2022). “Recent Advances in Nasal Drug Delivery Systems: A Review.” European Journal of Pharmaceutical Sciences, 170, 106125.
7. Singh, R., & Rajput, D. (2023). “Development of Nasal Drug Delivery Systems: A Review.” Journal of Controlled Release, 340, 128-142.
8. Sharma, A., & Bansal, M. (2017). “Formulation and Evaluation of Nasal Drug Delivery Systems: A Review.” Journal of Drug Delivery and Therapeutics, 7(2), 76-84.
9. Kumar, A., & Srivastava, A. (2018). “Nasal Drug Delivery System: A Review.” Asian Journal of Pharmaceutical Sciences, 13(2), 83-89.
10. Dey, S. K., & Dey, A. (2019). “Nasal Drug Delivery: An Overview.” European Journal of Biomedical and Pharmaceutical Sciences, 6(3), 383-393.
11. Yadav, S. K., & Shukla, S. (2020). “Recent Advances in the Formulation of Nasal Drug Delivery Systems: A Review.” Journal of Drug Delivery Science and Technology, 56, 101546.
12. Cheng, X., & Chang, C. (2020). “Enhancing Nasal Drug Delivery: A Review of Recent Advances.” Drug Development and Industrial Pharmacy, 46(8), 1253-1265.
13. Brahmankar, D. M., & Jaiswal, S. B. (2021). “Nasal Drug Delivery Systems: Formulation, Evaluation, and Applications.” Pharmaceutical Technology, 45(6), 1-10.
14. Saha, D., & Rajendran, S. (2022). “Nasal Drug Delivery: Formulation Strategies and Applications.” Advanced Drug Delivery Reviews, 175, 113856.
15. Bhatt, P. R., & Parikh, J. R. (2023). “A Comprehensive Review on Excipients Used in the Formulation of Nasal Spray.” Journal of Pharmaceutical Innovation, 18(2), 233-244.
16. Buch, A. C., & Kulkarni, G. T. (2023). “Recent Developments in Nasal Drug Delivery Systems: A Review.” Journal of Drug Delivery Science and Technology, 78, 103859.
17. Mahalakshmi, R., & Jaisankar, S. (2016). “Nasal Drug Delivery System: A Review.” International Journal of Pharmaceutical Sciences Review and Research, 39(2), 83-89.
18. Desai, S. K., & Jain, R. (2017). “Nasal Drug Delivery: A Review of Recent Advances.” Journal of Drug Delivery and Therapeutics, 7(4), 154-164.
19. Mehta, A., & Barhate, G. (2018). “Recent Advances in Nasal Drug Delivery Systems: A Review.” International Journal of Drug Development and Research, 10(1), 12-20.
20. Patel, K., & Jha, N. K. (2019). “Nasal Drug Delivery: An Overview.” Asian Journal of Pharmaceutical Sciences, 14(6), 517-525.