Volume : 12, Issue : 01, January – 2025
Title:
A REVIEW ON THE STABILIZING AGENT USED FOR PHARMACEUTICAL FORMULATION
Authors :
Sanjana Shridhar walwante, Payal Ramesh Gaikwad, Nandkishor Deshmukh, Dr. Swati Deshmukh
Abstract :
Stabilizing agents play a crucial role in pharmaceutical formulations by maintaining the physical, chemical, and biological integrity of active pharmaceutical ingredients (APIs) during manufacturing, storage, and administration. These agents protect APIs from degradation caused by environmental factors such as temperature, light, moisture, and oxygen. Common stabilizers include antioxidants, preservatives, buffering agents, and surfactants, each tailored to address specific stability challenges. The selection of appropriate stabilizing agents is essential for extending shelf life, ensuring efficacy, and enhancing patient safety. This review discusses the mechanisms of action, types, and applications of stabilizers in various pharmaceutical dosage forms, emphasizing their importance in the development of stable and effective therapeutic products.
Key Words: Stabilizing agents Pharmaceutical formulation Active pharmaceutical ingredients (APIs)Degradation Antioxidants Preservatives Buffering agents Surfactants Shelf life drug stability Efficacy Dosage forms Environmental factors Drug formulation development.
Cite This Article:
Please cite this article in press Sanjana Shridhar walwante et al., A Review On The Stabilizing Agent Used For Pharmaceutical Formulation.,Indo Am. J. P. Sci, 2025; 12 (01).
Number of Downloads : 10
References:
1 Aulton, M. E., & Taylor, K. M. G. (2017). Alton’s Pharmaceutics: The Design and Manufacture of Medicines. (5th edition). Elsevier.
2. Allen, L. V., Popovich, N. G., & Ansel, H. C. (2020). Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems. (11th edition). Wolters K
3. Carstensen, J. T., & Rhodes, C. T. (2000). Drug Stability: Principles and Practices. (3rd edition).
4. Lachman, L., Lieberman, H. A., & Kanig, J. L. (1986). The Theory and Practice of Industrial Pharmacy. (3rd edition). Lea & Febiger.
5. “Handbook of Pharmaceutical Excipients” by Raymond C. Rowe, Paul J. Sheskey, and Marian E. Quinn
6.“Remington: The Science and Practice of Pharmacy” (22nd Edition)
7.“Pharmaceutical Preformulation and Formulation: A Practical Guide from Candidate Drug Selection to Commercial Dosage excipients for stabilizing formulations, with discussions on their chemical and physical stability.
8.“Stability of Drugs and Dosage Forms” by Sumie Yoshioka and Valentino J. Stella
9.“Pharmaceutical Stability Testing to Support Global Markets” by Kim Huynh-Ba
10.“Pharmaceutical Dosage Forms: Tablets, Volume 1 – Unit Operations and Mechanical Properties” edited by Larry L. Augsburger and Stephen W. Hoag
11.“International Journal of Pharmaceutics
12.U.S. Pharmacopeia (USP) and National Formulary
13. 9. “Pharmaceutical Formulation Development of Peptides and Proteins” by R. S. P. Chan and J. H. F. P. van de Sweet
14. “Biopharmaceuticals: Biochemistry and Biotechnology” by Gary Walsh
15. “Pharmaceutical Formulation and Quality” by Angela M. Smith and N. Robert Jones
16. “Pharmaceutical Technology: Drug Product Development” by Nirmal Kumar Sahoo
17. “Stability of Pharmaceutical Dosage Forms” by T. E. Williams, J. S. Weller, and K. L. Tully in Journal of Pharmaceutical.
18. “Formulation Strategies for the Development of Biopharmaceuticals” by R. M. Prathapan and D. M. R. Jones in Nature Reviews Drug.
19. “The Role of Surfactants in Pharmaceutical Formulations” by P. A. E. Pluim et al. in European Journal of Pharmaceutical Science’.
20. “Strategies for Stabilization of Proteins and Peptides” by J. K. B. W. K. Y. V. et al. in Molecular Pharmaceutics.
21. “Guidelines on Stability Testing of New Drug Substances and Products” by the International