Volume : 12, Issue : 01, January – 2025
Title:
PHARMACOLOGICAL AND WOUND HEALING PROPERTIES OF TRIDAX PROCUBENS
Authors :
Kalyani N. Sadafale*, Tejal P. Bute*, Aditya A. Unhale , Dr.Swati P. Deshmukh
Abstract :
Wound healing is a complex biological process involving the restoration of cellular, anatomical, and functional integrity following injury. The process can be hindered in certain conditions, such as diabetes mellitus, which is known to impair wound healing, resulting in chronic wounds. This poses a significant health burden globally. While traditional treatments exist, their effectiveness is not always guaranteed, and there is a growing need for more reliable therapeutic alternatives. This paper explores the potential repurposing of existing drugs—such as dipeptidyl peptidase 4 (DPP4) inhibitors, metformin, statins, and phenytoin—as treatment options for chronic wounds, based on preclinical and clinical findings.
In addition to pharmaceutical approaches, traditional herbs have been widely utilized for wound healing, with Tridax procumbens (TP) emerging as a promising candidate. Known for its antimicrobial, anti-inflammatory, and antioxidant properties, TP accelerates wound healing through various mechanisms. TP has shown potential in treating a wide range of conditions, including infections, inflammation, and skin wounds. Its chemical constituents, such as flavonoids (quercetin, luteolin, apigenin), contribute to its wound-healing properties by reducing oxidative stress and inflammation. TP’s medicinal uses extend beyond wound care, encompassing liver protection, pain relief, antidiabetic effects, and antimicrobial activity, among others.
Key Points :-Wound Healing Process ,. Chronic Wounds, Tridax Procumbens (TP) , Wound Healing Mechanisms , Antimicrobial & Antidiabetic
,
Cite This Article:
Please cite this article in press Kalyani N. Sadafale et al., Pharmacological And Wound Healing Properties Of Tridax Procubens.,Indo Am. J. P. Sci, 2025; 12 (01).
Number of Downloads : 10
References:
1. USDA. Tridax procumbens. Natural Resources Conservation Service PLANTS Database. 2015 Dec 15.
2. Tridax procumbens L. Encyclopedia of Life. Available from: https://en.wikipedia.org/wiki/Tridax_procumbens
3. Baker S, Sreedharamurthysatish. Bioprospecting of endophytic bacterial plethora from medicinal plants. Plant Sci Feed. 2013;3(3):42-45.
4. Wikipedia, the free encyclopedia. Tridax procumbens. Available from: https://en.wikipedia.org/wiki/Tridax_procumbens
5. Gamboa-Leon R, Vera-Ku M, Peraza-Sanchez SR, Ku-Chulim C, Horta-Baas A, Rosado-Vallado M. Antileishmanial activity of a mixture of Tridax procumbens and Allium sativum in mice. Parasite. 2014;21:15. Doi:10.1051/parasite/2014016.
6. Petchi R, Vijaya C, Parasuraman S. Anti-arthritic activity of ethanolic extract of Tridax procumbens (Linn.) in Sprague Dawley rats. Pharmacognosy Res. 2013;5(2):113-117. Doi:10.4103/0974-8490.110541.
7. Ali M, Ravinder E, Ramachandram R. A new flavonoid from the aerial parts of Tridax procumbens. Fitoterapia. 2001;72(3):313-315. Doi:10.1016/S0367-326X(00)00296-3.
8. Pathak AK, Saraf S, Dixit VK. Hair growth promoting activity of Tridax procumbens. Fitoterapia. 1991;62:307-313.
9. Deshmukh AS, Morankar PG, Kumbhare MR. Review on analgesic activity and determination methods. Pharmtechmedica. 2014;3(1):425-428.
10. Vilwanathan R, Shivashangari KS, Devak T. Hepatoprotective activity of Tridax procumbens against D-galactosamine/lipopolysaccharide-induced hepatitis in rats. J Ethnopharmacol. 2005;101:55-60.
11. Oladunmoye MK. Immunomodulatory effects of ethanolic extract of Tridax procumbens on Swiss Albino rats orogastrically dosed with Pseudomonas aeruginosa (NCIB 950). Int J Trop Med. 2006;1(4):152-155.
12. Bhat RS, Shankrappa J, Shivakumar HG. Formulation and evaluation of polyherbal wound treatments. Asian J Pharm Sci. 2007;2(1):11-17.
13. Nia R, Paper DH, Essien EE, Oladimeji OH, Iyadi KC, Franz G. Investigation into in-vitro radical scavenging and in-vivo anti-inflammatory potential of Tridax procumbens. Niger J Physiol Sci. 2003;18(1-2):39-43.
14. Bhagwat DA, Killedar SG, Adnaik RS. Antidiabetic activity of leaf extract of Tridax procumbens. Int J Green Pharma. 2008;2:126-128.
15. Mahato RB, Chaudhary RP. Ethnomedicinal study and antibacterial activities of selected plants of Palpa district, Nepal. Sci World. 2005;3(3):26-31.
16. Opong RA, Nyarko AK, Dodoo D, Gyang FN, Koram KA, Ayisi NK. Antiplasmodial activity of extracts of Tridax procumbens and Phyllanthus amarus in in-vitro Plasmodium falciparum culture systems. Ghana Med J. 2011;45(4):143-150.
17. Sankaranarayanan S, Bama P, Sathyabama S, Bhuvaneswari N. Anticancer compound isolated from the leaves of Tridax procumbens against human lung cancer cell A-549. Asian J Pharm Clin Res. 2013;6(2):91-96.
18. Jindal A, Kumar P. In vitro antifungal potential of Tridax procumbens L. Against Aspergillus flavus and Aspergillus niger. Asian J Pharm Clin Res. 2013;6(2):123-125.
19. Pai C, Kulkarni U, Borde M, Murali S, Mrudula P, Deshmukh Y. Antibacterial activity of Tridax procumbens with special reference to nosocomial pathogens. Br J Pharm Res. 2011;1(4):164-173.
20. Agrawal SS, Talele GS, Surana SJ. Antioxidant activity of fractions from Tridax procumbens. J Pharm Res. 2009;2(1):71-73.




