Volume : 12, Issue : 02, February – 2025

Title:

FORMULATION AND EVALUATION OF CURCUMIN LOADED CHITOSAN TOPICAL GEL FOR WOUND HEALING
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Authors :

Heeshan Raju.R., Gayathri.S., Khaviya.M., Keerthana.V., Devika.M., Mrs. A. Chandra

Abstract :

Wound healing is a complex physiological process that requires effective therapeutic interventions to promote tissue regeneration and prevent infections. In this study, we developed and evaluated a curcumin-loaded chitosan-based topical gel for its potential wound-healing properties. Curcumin, a bioactive compound with well-documented anti-inflammatory, antioxidant, and antimicrobial properties, was incorporated into a chitosan to enhance its bioavailability and therapeutic efficacy. Carboxymethyl cellulose (CMC) was added to improve the gel’s stability, viscosity, and skin adhesion properties.
The gel was prepared using an optimized formulation of chitosan, CMC, and curcumin, ensuring a homogeneous distribution of the active ingredient. Physicochemical characterization, including viscosity, pH, swelling capacity, and drug release studies, was conducted to evaluate the gel’s properties. In vitro drug release studies indicated a sustained and controlled release of curcumin, which is essential for prolonged therapeutic action.
Histopathological analysis confirmed enhanced collagen deposition, reduced inflammation, and accelerated tissue regeneration. These findings suggest that the curcumin-loaded chitosan-CMC gel is a promising biomaterial for wound healing applications, offering an effective and biocompatible alternative to conventional treatments.
Keywords: Curcumin, Chitosan, Carboxymethyl Cellulose, Gel, Wound Healing, Drug Delivery

Cite This Article:

Please cite this article in press Heeshan Raju.R et al Formulation And Evaluation Of Curcumin Loaded Chitosan Topical Gel For Wound Healing.,Indo Am. J. P. Sci, 2025; 12 (02).

Number of Downloads : 10

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