Volume : 11, Issue : 08, August – 2024
Title:
FABRICATION AND CHARACTERIZATION OF BUCCOADHESIVE FILMS OF LEVETIRACETAM FOR TRANSMUCOSAL DRUG DELIVERY AND ASSAY BY USING UPLC
Authors :
C. Muralikrishna Goud*, Dr. Sumer Singh
Abstract :
The aim of the present study was to formulate and evaluate buccoadhesive films of model drug, levetiracetam indented as an alternate route of drug delivery to have enhanced bioavailability. The bilaminated buccoadhesive films were prepared by solvent casting technique. Backing membrane was prepared by using ethyl cellulose, acetone, isopropyl alcohol and dibutyl phthalate where as drug loaded buccoadhesive membrane was prepared by using carbopol 934P, sodium alginate, distilled water and glycerol. All formulations of prepared films were evaluated for thickness, surface area, weight variation, mucoadhesion strength, folding endurance, chemical incompatibility and thermal studies. The invitro diffusion studies were conducted by using franz diffusion cells. Drug assay was carried out by developing a new method for UPLC.
Key words: Buccoadhesive films, buccal route, onset of action, first pass effect, dosage form
Cite This Article:
Please cite this article in press C. Muralikrishna Goud et al., Fabrication And Characterization Of Buccoadhesive Films Of Levetiracetam For Transmucosal Drug Delivery And Assay By Using UPLC., Indo Am. J. P. Sci, 2024; 11 (08).
Number of Downloads : 10
References:
1. Yang X, Robinson JR. Bioadhesion in Mucosal Drug Delivery. In: Okano T, editor.Biorelated Polymers and Gels. ondon: Academic Press; 1998. [GoogleScholar].
2. GuJM, Robinson JR, LeungSH.Binding of acrylic polymers to mucin/epithelial surfaces: Structure property relationships. Crit RevTher Drug Carrier Syst. 1988; 5:21–67. [PubMed] [GoogleScholar]
3. Smart JD, Nicholls TJ, GreenKL, Rogers DJ, CookJD. Lectins in Drug Delivery: a study of the acute local irritancy of the lectins from Solanum tuberosum and helix pomatia. Eur J Pharm Sci. 1999;9:93–8. [PubMed] [Google Scholar]
4. Naisbet tB, Woodley J. The potential use of tomato lectin for oral drug delivery. IntJ Pharm. 1994; 107:223–30. [Google Scholar]
5. Nicholls TJ, Green KL, Rogers DJ, Cook JD, Wolowacz S, Smart JD. Lectins in ocular drug delivery. An investigation of lectin binding sites on the corneal and conjunctival surfaces. Int J Pharm. 1996;138:175–83. [Google Scholar]
6. Horno fM, Weyenberg W, Ludwig A, Bernkop – Schnurch A. A mucoadhesive ophthalmic insert based on thiolated poly(acrylic) acid: Development and invivo evaluation in human volunteers. J Control Release. 2003; 89: 419 –28. [PubMed] [GoogleScholar]
7. Albrecht K, Zirm EJ, Palmberger TF, Schlocker W, Bernkop-Schnurch A. Preparation of thiomer microparticles and invitro evaluation of parameters influencing their mucoadhesive properties. Drug Dev Ind Pharm. 2006;32:1149–57. th. [PubMed] [GoogleScholar]
8. Peppas NA, Little MD, Huang Y. Bioadhesive Controlled Release Systems. In: Wise DL, editor. Handbook of pharmaceutical controlled release technology. New York: Marcel Dekker; 2000. pp. 255–69. [Google Scholar]
9. Gurny R, Meyer JM, Peppas NA. Bioadhesive intra oral release systems: Design, testing and analysis. Biomaterials. 1984;5:336–40. [PubMed] [Google Scholar]
10. Gudeman L, Peppas NA. Preparation and characterisation of ph- sensitive, inter penetrating networks of poly (vinylalcohol) and poly (acrylicacid) J Appl Polym Sci. 1995;55:919–28. [Google Scholar]
11. McCarron PA, Woolfson AD, Donnelly RF, Andrews GP, Zawislak A, Price JH. Influence of plasticizer type and storage conditions on the properties of poly (methylvinyl ether-co-maleic anhydride) bioadhesive films. J Appl Polym Sci. 2004;91:1576–89. [GoogleScholar]
12. Blanco Fuente H, AnguianoIgea S, Otero Espinar FJ, Blanco Mendez J. In-vitro bioadhesion of carbopol hydrogels. Int J Pharm. 1996;142:169–74. [GoogleScholar]