Volume : 12, Issue : 04, April – 2025
Title:
PHARMACOLOGICAL EVALUATION OF CATECHIN ON KINDLING ASSOCIATED POST-ICTAL DEPRESSION IN RAT
Authors :
Dhananjay Narsale*, Dr. Kamble H.V, Mr. Sugriv R. Ghodake, Dr. A.D Kandhare,Ms. Sonal S. Ithape
Abstract :
This study investigates the potential therapeutic effects of catechin, a natural phenolic compound, in PTZ-induced epilepsy, focusing on its anticonvulsant, antioxidant, and neuroprotective properties. Catechin was administered at various doses (50, 100, 200 mg/kg) to evaluate its impact on seizure intensity, convulsion onset, neurotransmitter levels, and post-ictal depression. The results showed that catechin significantly reduced seizure severity, delayed convulsion onset, and improved locomotor activity, particularly at higher doses (200 mg/kg). Additionally, catechin modulated neurotransmitter levels, including serotonin, dopamine, and GABA, and reduced oxidative stress markers, such as SOD and GSH. It also alleviated depression-like symptoms, suggesting catechin’s potential to modulate the hypothalamic-pituitary-adrenal (HPA) axis and the central noradrenergic system. These findings highlight catechin’s therapeutic potential for managing epilepsy-related behaviors and post-ictal depression, positioning it as a promising natural compound for future clinical applications.
Keywords: Catechin, PTZ-induced epilepsy, anticonvulsant effects, , neuroprotection, depression-like symptoms, neurotransmitters, oxidative stress, serotonin, dopamine, post-ictal depression.
Cite This Article:
Please cite this article in press Dhananjay Narsale et al., Pharmacological Evaluation Of Catechin On Kindling Associated Post-Ictal Depression In Rat, Indo Am. J. P. Sci, 2025; 12(04).
Number of Downloads : 10
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