Volume : 12, Issue : 03, March – 2025
Title:
FORMULATION AND EVALUATION GASTRORETENTIVE DRUG DELIVERY SYSTEM
Authors :
Niesh M.Jadhao, Aijaz A.Sheikh, K.R.Biyani
Abstract :
Gastroretentive Drug Delivery Systems (GRDDS) represent a significant advancement in the field of oral drug delivery, offering enhanced bioavailability, controlled release profiles, and improved therapeutic outcomes for drugs with narrow absorption windows or those unstable in the intestinal pH. Through various approaches—such as floating, mucoadhesive, expandable, high-density, and raft-forming systems—GRDDS has proven effective in extending gastric residence time and improving the pharmacokinetics of a wide range of therapeutic agents.
The advantages of GRDDS, including reduced dosing frequency, enhanced patient compliance, and minimized side effects, position it as a preferred choice for chronic conditions requiring sustained drug delivery. However, the challenges associated with these systems—such as variable gastric emptying times, potential for dosage form failure, and formulation complexity—require careful design and evaluation during development. Furthermore, the influence of physiological factors such as pH, gastric motility, and fed or fasted state must be considered to ensure consistent drug release and absorption.
As explored in this chapter, GRDDS has demonstrated potential in treating various gastrointestinal and systemic diseases, including Helicobacter pylori infections, peptic ulcers, GERD, diabetes, and hypertension. This versatility is driving ongoing research to develop more reliable, patient-friendly formulations that align with individual patient needs and clinical outcomes. In conclusion, the continued evolution of GRDDS will likely play a pivotal role in the advancement of oral pharmacotherapy, enabling precise, targeted, and effective treatment options in both conventional and novel therapeutic areas.
Cite This Article:
Please cite this article in press Niesh M.Jadhao et al., Formulation And Evaluation Gastroretentive Drug Delivery System., Indo Am. J. P. Sci, 2025; 12(05).
Number of Downloads : 10
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