Volume : 12, Issue : 03, March – 2025

Title:

ISOLATION, CHARACTERIZATION, ANTIBACTERIAL ACTIVITY, AND SCREENING USING UV-FTIR TECHNIQUES OF CUVULARIA SP. FROM T. CORDIFOLIA

Authors :

Sunitha. B.R, Ashwini*, Y. R. Karthik, Padmalatha. S. Rai and Y.L. Ramachandra

Abstract :

Medicinal plants are frequently utilized in therapy because of their natural therapeutic properties and the existence of bioactive chemicals that can treat a variety of ailments. Medicinal plants are employed in phytotherapy, which is the utilization of plant extracts and active substances to promote health and aid the body’s natural healing processes. Secondary metabolites found in herbal plants, such as flavonoids, flavones, anthocyanins, lignans, and coumarins, have been proven to show anticancer activities. The current study demonstrated that secondary metabolites exhibit a range of bioactive compounds. The endophyte extract from Cuvularia sp was tested against several bacteria, including E. coli, S. aureus, B. subtilis, K. pneumoniae, P. aeruginosa, and P. syringae, and it demonstrated a zone of inhibition against these bacteria. Endophytic extract characterisation is utilized for several analytical methods, including FTIR, which finds functional groups including, O–H (alcohols, Phenols), C-H (Alkanes), C=C (Alkenes), C-C (Aromatic rings), C-N (Aliphatic Amines), N-H (1°, 2° Amines). The present study evaluates Curvularia sp samples for UV-Vis spectrophotometric analysis, identifies significant bioactive compounds, including carotenoids, flavonoids, photosensitive proteins, chromophores, phenolic groups, nucleic acids, etc, which are all helpful for the preparation of pharmaceutical drugs, and also shows the antioxidant, anticancer activity.
KEYWORDS: Anti-cancer activity, Cuvularia sp, FTIR, UV-Vis, Photosensitive,

Cite This Article:

Please cite this article in press Sunitha, B.R et al., Design, Isolation, characterization, antibacterial activity, and screening using uv-ftir techniques of cuvularia sp. From t. Cordifolia., Indo Am. J. P. Sci, 2025; 12(05).

Number of Downloads : 10

References:

1. Visagie C. M, Hirooka. Y, Tanney J. B, Whitefield. E, Wange K.M, Meijer. M, Amend A.S, Seifert K.A, Samson R. A. 2014. Aspergillus, Penicillium, and Talaromyces Isolated from house dust samples collected around the world. Study in Mycology. Vol. 78;63-1639. https://dx.doi.org/10.1016/j.simyco.2014.07.002.
2. Barnett H.L, Hunter B. B. 1998. Illustrated gene of imperfect fungi, 4th edn. The American Phytopathological Society, St.Paul.
3. Garima Bartariya, Abhishek Kumar, Basant Kumar. 2017. Qualitative and Quantitative estimation of total phenolics and total flavonoids in leaves extract of Saraca asoca (Roxb). Indo-American Journal of Pharmaceutical Sciences; Sanjana Mishra, Navneet Kumar Verma, Tarun Kumar. 2024. Herbal Treatment of Pneumonia (Treatment of Pneumonia from Medicinal Plants): A Review. Scholars’ Academic Journal of Pharmacy.
4. Potmesil Milan. 1994. Camptothecins: From Bench Research to Hospital Wards. Cancer Research Vol.54 Issue 6 (1431-1439).
5. Van-Hengel A.J, Harkesh M.P, Wichers H.J, Hesselink P.G and Buitelaar R.M.1992. Characterization of callus formation and Camptothecin production by cell lines of Camptotheca accuminata. Plant cell tiss.org. cult. Vol. 28;11-18.
6. Aiyama R, Nagai H, Kokata, Shinonava Y, Sawada C, 1998. A Camptothecin derivatives from
Nothapodytes foetida. Phytochemistry. Vol. 27;3664-3666.
7. Sarath P. Gunasekera, Geoffrey, Cordell A, and Norman R, Farnsworth. 1979. Potential anticancer agents 14. Isolation of Spruceanol and Montanin from Cunuria spruceana. Journal of Natural Products.Vol. 42 (6);658-662.https://doi.org/10.1021/np50006a012.
8. Padmanabh Dwivedi, Prasann Kumar 2006. Anti-diabetic medicinal plants and their conservation, waging a green war on diabetes. Medicinal plants International Journal of Phytomedicines and Related Industries. Vol.3(3); 181-189.doi-10.5958/j.0975-4261.3.3.031.
9. Singh, Vivek Bajpai, Gurav A.M, Lavekar G.S. 2007. Antimicrobial activity of some Indian Medicinal plants. African Journal of Traditional Complementary and Alternative Medicines.Vol. 4 (3); 313-318; Athiralakshmy T.R, Divyamol A.S and Nisha P. 2016. Phytochemical Screening of Saraca asoca and Antimicrobial Activity against Bacterial Species. Asian Journal of Plant Science and Research. Vol. 6(2);30-36.
10. Shardul S. Kulkarni, Ratnakar B. Lanjewar and Sunita M. Gadegone. 2016. A review on levodopa and beta-sitosterol and its pharmacological actions in Bauhinia recemosa, Canavalia gladiata, and Vigna vexillata medicinal plants. Journal of Medicinal Plant Studies. Vol. 4 (4): 259-264.
11. Sumangala R.C, Sachin Rosario, Bipin Charles, Ganesh D, and Ravikanth G. 2017. Identifying conservation priority sites for Saraca asoca: An important medicinal plant using ecological niche models. Vol. 143 (6); 531-536, https://www.indianforester.co.in.
12. Isha Kumari, Hemlata Kaurav, Gitika Chaudhary 2021. Eclipta alba(bhringraj): A promising hepatoprotective and hair growth-stimulating herb. Asian Journal of Pharmaceutical and Clinical Research. Vol.14(7), https://dx.doi.org/10.22159/ajpcr.2021v14i7.41569.