Volume : 12, Issue : 06, June – 2025

Title:

FORMULATION AND EVALUATION OF FAST DISINTEGRATING TABLETS OF PIROXICAM USING DIFFERENT SUPER DISINTEGRANTS

Authors :

Afreen Banu*, Dr.T.Mangilal, Shohab Zeba, K.Pallavi, K.Bhasker, Syed Saif.

Abstract :

The scenarios of pharmaceutical drug delivery are expeditiously challenging, but conventional pharmaceutical dosage forms are still dominating. Fast disintegrating dosage forms are those wherein ≥85% of labeled amount dissolves within 1 min. Superdisintegrants are used to improve the efficacy of solid dosage forms. The basic approach used in the formulation of the tablet is the use of super disintegrants like SCMC , sodium starch glycolate, and starch 1500, etc. These super disintegrants provide instantaneous disintegration of the tablet after administration in the stomach. Thus, decreasing the disintegration time which in turn enhances drug dissolution rate. The rapid disintegration may be due to the rapid uptake of water from the medium, swelling, burst effect and thereby promoting bioavailability. Tablets formulations are mostly preferred because of the low cost of manufacture, package, shipment, increased stability. For the obtained formulations evaluation studies are carried out. Weight variation, Hardness, Drug content values were found to be within standard limits prescribed. In vitro studies carried out using disintegration apparatus and all the formulations showed release between 70-90%.
Keywords: Piroxicam, Fast disintegrating , super disintegrants, SCMC,starch 1500, sodium starch glycolate, Evaluation studies.

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