Volume : 12, Issue : 08, August- 2025
Title:
INFLUENCE OF COMORBID CONDITIONS ON TIMELY ANTIBIOTIC DE-ESCALATION IN RESPIRATORY TRACT INFECTIONS
Authors :
Sharon Wilson, Tintu Thomas, Ancy Anil, Angelin Ann Anil, Dr. Elizabeth James, Abhilash Kumar
Abstract :
De-escalation generally refers to the process of reducing the spectrum of antibiotic therapy by either discontinuing unnecessary agents or switching to a narrower-spectrum antibiotic based on clinical response and microbiological data. Here we presents a study on Effect of comorbidities on De-Escalation of Antibiotics in Respiratory Tract Infections.
Keywords: Antibiotic De-escalation , RTIs, Comorbidities, KM -Curves
Cite This Article:
Please cite this article in press Sharon Wilson et al., Influence Of Comorbid Conditions On Timely Antibiotic De-Escalation In Respiratory Tract Infections., Indo Am. J. P. Sci, 2025; 12(08).
Number of Downloads : 10
References:
1) Shrestha J, Zahra F, Cannady J. Antimicrobial Stewardship [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2021. Available from: https://www.ncbi.nlm.nih.gov/books/NBK572068/
2) Rupali P, Dtm&h, Frcp. Introduction to antimicrobial stewardship and Principles of Antimicrobial prescribing [Internet]. Available from: https://cdn.who.int/media/docs/default-source/searo/essential-medicines/presentation-introduction-to-antimicrobial-stewardship-and-principles-of-antimicrobial-prescribing.pdf?sfvrsn=59bab377_1
3) Fishman N. Antimicrobial Stewardship. The American Journal of Medicine. 2006 Jun;119(6): S53–61.
4) Dellit TH, Owens RC, McGowan JE, Gerding DN, Weinstein RA, Burke JP, et al. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America Guidelines for Developing an Institutional Program to Enhance Antimicrobial Stewardship. Clinical Infectious Diseases [Internet]. 2007 Jan15;44(2):159–77.Availablefrom: https://academic.oup.com/cid/article/44/2/159/328413
5) Prachi Tayal et al, “ Antibiotics medication prescribed in the management of respiratory tract infection of tertiary care teaching hospital’, Journal of Young Pharmacists 13(3):262-266 ,DOI:10.5530/jyp.2021.13.53
6) Rivero-Calle I, Cebey-López M, Pardo-Seco J, Yuste J, Redondo E, Vargas DA, Mascarós E, Díaz-Maroto JL, Linares-Rufo M, Jimeno I, Gil A, Molina J, Ocaña D, Martinón-Torres F. Lifestyle and comorbid conditions as risk factors for community-acquired pneumonia in outpatient adults (NEUMO-ES-RISK project). BMJ Open Respir Res. 2019 Mar 12;6(1):e000359. doi: 10.1136/bmjresp-2018-000359. PMID: 31178994; PMCID: PMC6530500.
7) Murray CJ, Ikuta KS, Sharara F, Swetschinski L, Aguilar GR, Gray A, Han C, Bisignano C, Rao P, Wool E, Johnson SC. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. The lancet. 2022 Feb 12;399(10325):629-55.
8) Das S. Haque I, Gaur A, Suhail Mustafa M. de-escalation pattern of antibiotics in the medical intensive care unit of a tertiary care hospital in north India. World Journal of Pharmacy and Pharmaceutical Sciences, 2020 Jan 9:1451-1460
9) WHO EMRO | What is the difference between antibiotic and antimicrobial resistance? | Antimicrobial resistance | Health topics [Internet]. www.emro.who.int. Available from: https://www.emro.who.int/health-topics/drug-resistance/what-is-the-difference-between-antibiotic-and-antimicrobial-resistance.html
10) Britannica. Antibiotic | chemical compound. In: Encyclopedia Britannica [Internet]. 2019. Available from: https://www.britannica.com/science/antibiotic
11) Aminov RI. A brief history of the antibiotic era: lessons learned and challenges for the future. Frontiers in microbiology. 2010 Dec 8; 1:134. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109405/
12) Ullah H, Ali S. Classification of Anti‐Bacterial Agents and Their Functions [Internet]. www.intechopen.com. IntechOpen; 2017. Available from: https://www.intechopen.com/chapters/55303
13) Antimicrobial Resistance Collaborators. Global Burden of Bacterial Antimicrobial Resistance in 2019: A Systematic Analysis. The Lancet [Internet]. 2022 Jan 19;399(10325):629–55.Availablefrom: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02724-0/fulltext