Volume : 12, Issue : 08, August- 2025
Title:
DEVELOPMENT AND VALIDATION OF A NEW ANALYTICAL UV SPECTROSCOPIC METHOD FOR ANALYSIS OF DONEPEZIL IN BULK POWDER AND TABLET DOSAGE FORM
Authors :
Srilaxmiprasanna*, S.Sneha, N.Shirisha, M.Poojitha, Karthik
Abstract :
A new simple, accurate, rapid, precise, reproducible and cost effective spectrophotometric method for the quantitative estimation of Donepezil in bulk and pharmaceutical dosage form. The developed visible spectrophotometric method for the quantitative estimation of Donepezil is based on measurement of absorption at maximum wavelength 278 nm using methanol as a solvent. The stock solution of Donepezil was prepared, and subsequent suitable dilution was prepared in distilled water to obtained standard curve. The standard solution of Donepezil shows absorption maxima at 278 nm. The drug obeyed beer lambert’s law in the concentration range of 0-60 μg/ml with regression 0.999 at 278 nm. The overall % recovery was found to be 100.167% which reflects that the method was free from the interference of the impurities and other excipients used in the bulk and marketed dosage form. The low value of % RSD was indicative of accuracy and reproducibility of the method. The % RSD for precision was found to be 0.864%. The %RSD for inter-day and intra-day precision was found to be 0.807 and 0.881 respectively which is <2% hence proved that method is precise. The results of analysis have been validated as per International Conference on Harmonization (ICH) guidelines. The developed method can be adopted in routine analysis of Donepezil in bulk and tablet dosage form.
Keywords: Donepezil, UV-Spectrophotometry, Methanol, Accuracy, Precision.
Cite This Article:
Please cite this article in press Srilaxmiprasanna et al., Development And Validation Of A New Analytical Uv Spectroscopic Method For Analysis Of Donepezil In Bulk Powder And Tablet Dosage Form., Indo Am. J. P. Sci, 2025; 12(08).
Number of Downloads : 10
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