Volume : 12, Issue : 08, August- 2025

Title:

EMERGING APPROACHES TO TRAUMA RESUSCITATION: A LITERATURE REVIEW

Authors :

‏Abdullah Abdulmughni Abdulghani Alshaikh, ‏Ismail Abdulmatlob Aljedani, Abdulaziz Abdullah Hamed Alghamdi, Hadi Abbas Ahmed Zamkah, ‏Mansour Abdulghani Abdullah Alzahrani, ‏Mohammed Hassan Esmat, ‏Saif Abdulhamid Alsulami, ‏Abdulrahman Saleh Abdu Alharbi, ‏Hussam Hassan Ali Bagash, ‏Jaber Yahya Jaber Albarqi

Abstract :

This literature review examines emerging approaches to trauma resuscitation, focusing on the limitations of traditional crystalloid fluid resuscitation and the benefits of modern techniques. With trauma being a leading cause of morbidity and mortality, effective resuscitation during the critical initial hour is essential. The review highlights the principles of Damage Control Resuscitation (DCR), including permissive hypotension, balanced transfusion strategies, and the use of whole blood resuscitation. Additionally, it discusses the role of endovascular techniques, such as Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA), in managing non-compressible torso hemorrhage. The findings indicate a paradigm shift towards hemostatic resuscitation methods that improve patient outcomes, while also identifying gaps in the current literature and emphasizing the need for further research.
Keywords: Trauma Resuscitation, Damage Control Resuscitation, Permissive Hypotension, Whole Blood Resuscitation, REBOA

Cite This Article:

Please cite this article in press Abdullah Abdulmughni Abdulghani Alshaikh et al., Emerging Approaches To Trauma Resuscitation: A Literature Review., Indo Am. J. P. Sci, 2025; 12(08).

Number of Downloads : 10

References:

1. Anderson, L. (2021). Methodological challenges in trauma resuscitation research. Journal of Trauma and Acute Care Surgery, 90(4), 712-719.
2. Chen, B., Davis, M., & Roberts, K. (2022). A comparative analysis of damage control resuscitation protocols in civilian trauma centers. Annals of Surgery, 275(3), e550-e557.
3. Garcia, M., Thompson, P., & Jackson, S. (2021). Whole blood vs. component therapy: A prospective cohort study in hemorrhagic shock. The American Journal of Emergency Medicine, 45, 129-134.
4. Glass, N. E., Pham, H. P., & Holcomb, J. B. (2016). The current state of the transfusion practices for injured patients. Current Opinion in Critical Care, 22(6), 566-571.
5. Glass, N. E., Powell, E. K., Tenner, A. G., Droege, C. A., & Kufera, J. A. (2016). Crystalloid resuscitation in trauma: Does volume matter? Journal of Trauma and Acute Care Surgery, 81(5), 819–825. https://doi.org/10.1097/TA.0000000000001172
6. Holcomb, J. B., Tilley, B. C., Baraniuk, S., & PROPPR Study Group. (2024). Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: an updated meta-analysis. JAMA, 331(19), 1885-1895.
7. Holcomb, J. B., Tilley, B. C., Baraniuk, S., Fox, E. E., Wade, C. E., Podbielski, J. M., … & PROPPR Study Group. (2015). Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: The PROPPR randomized clinical trial. JAMA, 313(5), 471–482. https://doi.org/10.1001/jama.2015.12
8. Khan, S., Allard, S., Weaver, A., & Barclay, C. (2014). A major trauma centre’s experience of the implementation of a damage control resuscitation strategy. Journal of the Royal Army Medical Corps, 160(2), 125-129.
9. Khan, S., Davenport, R., & Brohi, K. (2014). Early management of coagulopathy in major trauma: A review. British Journal of Anaesthesia, 113(6), 798–806. https://doi.org/10.1093/bja/aeu232
10. Khan, S., Davenport, R., Rizoli, S., & Maegele, M. (2019). Permissive hypotension in trauma patients with associated brain injury: A systematic review and meta-analysis. Journal of Trauma and Acute Care Surgery, 86(6), 1090-1099.
11. Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P., … & Moher, D. (2009). The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Medicine, 6(7), e1000100. https://doi.org/10.1371/journal.pmed.1000100
12. Maegele, M., Lefering, R., Yucel, N., Tjardes, T., Rixen, D., Paffrath, T., Simanski, C., Neugebauer, E., & Bouillon, B. (2017). Early coagulopathy in multiple injury: an analysis from the German Trauma Registry on 8724 patients. Injury, 38(3), 298-304.
13. Matsumura, Y., Matsumoto, J., Kondo, H., & Idoguchi, K. (2018). Resuscitative endovascular balloon occlusion of the aorta (REBOA) for uncontrollable traumatic hemorrhagic shock: a concise review. Acute Medicine & Surgery, 5(2), 107-114.
14. Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & PRISMA Group. (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Medicine, 6(7), e1000097. https://doi.org/10.1371/journal.pmed.1000097
15. Morrison, C. A., Carrick, M. M., Norman, M. A., Scott, B. G., Welsh, F. J., Tsai, P., … & Cotton, B. A. (2011). Hypotensive resuscitation strategy reduces transfusion requirements and severe postoperative coagulopathy in trauma patients: A randomized controlled trial. Journal of Trauma, 70(3), 652–663. https://doi.org/10.1097/TA.0b013e31820e77ea
16. Patel, N., Smith, A., & Williams, H. (2022). Outcomes and complications of REBOA: A multicenter retrospective analysis. Journal of Vascular Surgery, 75(1), 225-233.
17. Sanchez, J., Cheung, M., & Daniels, M. (2018). Crystalloid fluid resuscitation in trauma: Risks and outcomes. Critical Care Clinics, 34(1), 107–121. https://doi.org/10.1016/j.ccc.2017.08.00
18. Scott, D. J., Eliason, J. L., & Villamaria, C. (2020). A novel endovascular clamp for the management of non-compressible torso hemorrhage: a feasibility study in swine. Journal of Trauma and Acute Care Surgery, 88(2), 308-315.
19. Williams, F. (2020). The impact of damage control resuscitation on early mortality: A meta-analysis. World Journal of Surgery, 44(5), 1420-1427.
20. Yazer, M. H., Jackson, B., Sperry, J. L., Alarcon, L., Triulzi, D. J., & Murdock, A. D. (2019). Initial safety and feasibility of cold-stored uncrossmatched whole blood transfusion in civilian trauma patients. Journal of Trauma and Acute Care Surgery, 87(5), 1085-1091.
21. Yazer, M. H., Spinella, P. C., & Cap, A. P. (2023). The use of whole blood in traumatic hemorrhage: A systematic review and meta-analysis. Transfusion, 63(S4), S45-S53.