Volume : 12, Issue : 10, October – 2025
Title:
FORMULATION AND IN VITRO EVALUATION OF TRANSDERMAL PATCHES OF DEXKETOPROFEN TROMETAMOL USING HYDROPHILIC AND HYDROPHOBIC POLYMER COMPLEX
Authors :
Jampana Shivani*, Dr. K. Ramesh, Dr. Vijay Kumar Gampa, I. Nagaraju.
Abstract :
The present study focuses on the formulation and in vitro evaluation of transdermal patches of Dexketoprofen Trometamol using a combination of hydrophilic (HPMC) and hydrophobic (Ethyl Cellulose) polymer complexes, aiming to achieve sustained drug delivery and enhanced therapeutic efficacy. A series of formulations (F1–F8) were developed using varying ratios of the polymers and evaluated for physicochemical parameters such as thickness, weight uniformity, moisture content, folding endurance, tensile strength, drug content, and in vitro drug release.
Among the developed formulations, F1 was identified as the optimized formulation, exhibiting superior characteristics and a maximum drug release of 99.29% over 12 hours in dissolution studies. The controlled release profile observed in F1 suggests an effective interaction between the hydrophilic and hydrophobic polymers, facilitating sustained drug diffusion through the skin.
These findings indicate that transdermal patches containing Dexketoprofen Trometamol and a hydrophilic-hydrophobic polymer complex represent a promising alternative to conventional dosage forms, potentially improving patient compliance by reducing dosing frequency and maintaining consistent plasma drug levels.
Keywords: Formulation And In Vitro Evaluation Of Transdermal Patches Of Dexketoprofen Trometamol
Cite This Article:
Please cite this article in press Jampana Shivani et al., Formulation And In Vitro Evaluation Of Transdermal Patches Of Dexketoprofen Trometamol Using Hydrophilic And Hydrophobic Polymer Complex, Indo Am. J. P. Sci, 2025; 12(10).
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