Volume : 12, Issue : 10, October – 2025

Title:

FORMULATION AND IN VITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF ENTACAPONE USING HYDROPHILIC POLYMERS

Authors :

Lakkireddy Srivalli*, Dr. G.S. Valluri, Dr. Vijay kumar gampa. I. Nagaraju

Abstract :

The present study focuses on the formulation and in vitro evaluation of sustained release matrix tablets of Entacapone, a selective and reversible catechol-O-methyltransferase (COMT) inhibitor used in the management of Parkinson’s disease. Due to its short biological half-life and frequent dosing requirements, the development of a sustained release formulation was undertaken to enhance patient compliance and maintain steady plasma drug levels.
Matrix tablets were prepared using various hydrophilic polymers such as Hydroxypropyl Methylcellulose (HPMC), Carbopol, and Sodium Carboxymethyl Cellulose (NaCMC) by direct compression method. The pre-compression parameters (bulk density, tapped density, Carr’s index, Hausner ratio, and angle of repose) and post-compression parameters (hardness, thickness, friability, weight variation, drug content) were evaluated and found to be within acceptable limits.
In vitro drug release studies were carried out using USP dissolution apparatus, and the results showed that the rate of drug release was significantly influenced by the type and concentration of polymer used. Among the various formulations, E4 exhibited a sustained drug release up to 12 hours, releasing approximately 99.95% of the drug and followed Higuchi and Korsmeyer-Peppas kinetics, indicating a diffusion-controlled release mechanism.
The study concludes that hydrophilic polymers can effectively sustain the release of Entacapone from matrix tablets, offering a promising approach for the development of oral sustained release formulations to improve therapeutic efficacy and patient adherence.
Keywords: Entacapone sustained release matrix tablets

Cite This Article:

Please cite this article in press Lakkireddy Srivalli et al., Formulation And In Vitro Evaluation Of Sustained Release Matrix Tablets Of Entacapone Using Hydrophilic Polymers, Indo Am. J. P. Sci, 2025; 12(10).

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