Volume : 12, Issue : 10, October – 2025

Title:

ENHANCEMENT OF DISSOLUTION RATE OF CYPROHEPTADINE HCL BY SOLID DISPERSION METHOD

Authors :

Minhajul Islam Laskar*, P. Umadevi, Dr. D. Venkata Ramana

Abstract :

The present study was to investigate the technique in enhancement of dissolution rate of Cyproheptadine HCl using Solid dispersion method. Solid dispersion method of drug with carriers is a promising approach to alter the solid sate properties of drug substances like solubility and dissolution. The objective of the present work was to prepare, formulate and evaluate the Cyproheptadine HCl by screening various carriers. Cyproheptadine HCl were prepared by direct compression method. Orodispersible tablets of Cyproheptadine HCl were formulated, optimized and evaluated. The analysis of Infrared explicitly indicated the shifting of characteristic bands of Cyproheptadine HCl the orodispersible tablets of Cyproheptadine HCl were successfully prepared by direct compression method using Crospovidone, Croscarmellose sodium as Superdisintegrant with improved disintegration time (25 sec) and dissolution rate.
These results revealed that fast dissolving tablets of poorly soluble drug Cyproheptadine HCl, showing enhanced solubility and dissolution rate and hence better patient compliance.
Keywords: Cyproheptadine HCl, Croscarmellose sodium and orodispersible tablets.

Cite This Article:

Please cite this article in press Minhajul Islam Laskar et al., Enhancement Of Dissolution Rate Of Cyproheptadine Hcl By Solid Dispersion Method, Indo Am. J. P. Sci, 2025; 12(10).

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