Volume : 12, Issue : 10, October – 2025
Title:
FORMULATION AND EVALUATION OF TRANSDERMAL DURG DELIVERY SYSTEM OF HESPERIDIN
Authors :
Gandham Archana*, M. Mounika, Dr. D. Venkata ramana
Abstract :
The present study focuses on the formulation and evaluation of a transdermal drug delivery system (TDDS) of Hesperidin, a natural bioflavonoid known for its antioxidant, anti-inflammatory, and Vaso protective properties. Due to its poor oral bioavailability and extensive first-pass metabolism, the transdermal route was selected to enhance systemic absorption and ensure sustained therapeutic action. Transdermal patches were prepared using various combinations of polymers such as Ethyl Cellulose, HPMC and Eudragit RSPO, along with suitable plasticizers. The formulations were evaluated for physicochemical properties including thickness, weight variation, folding endurance, moisture content, drug content uniformity, and in vitro drug release. The optimized formulation exhibited good mechanical strength, satisfactory drug content, and a sustained drug release profile over 12 hours. The study concludes that Hesperidin-loaded transdermal patches can serve as a promising alternative to conventional dosage forms, potentially improving patient compliance and therapeutic efficacy.
Keywords: Hesperidin, Ethyl Cellulose, HPMC and Eudragit RSPO
Cite This Article:
Please cite this article in press Gandham Archana et al., Formulation And Evaluation Of Transdermal Durg Delivery System Of Hesperidin , Indo Am. J. P. Sci, 2025; 12(10).
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