Volume : 12, Issue : 10, October – 2025
Title:
FORMULATION AND EVALUATION OF IMMEDIATE-RELEASE TABLETS OF CENOBAMATE
Authors :
Boda roshini*, M. Mounika, Dr. D. Venkata Ramana.
Abstract :
The formulation and evaluation of immediate-release tablets of Cenobamate have demonstrated promising results in terms of both physical characteristics and performance. The tablets were successfully formulated with appropriate excipients, ensuring good flow properties, compressibility, and uniformity in weight and content. The in vitro dissolution studies indicated rapid and complete drug release, which is essential for achieving the desired therapeutic effect.
The results from the evaluation of Cenobamate immediate-release tablets confirm their potential for effective and rapid absorption in the body, making them a viable dosage form for patients requiring prompt therapeutic action. However, based on the formulation and evaluation, Cenobamate immediate-release tablets appear to be a promising candidate for the management of epilepsy and related conditions
Cite This Article:
Please cite this article in press Boda Roshini et al., Formulation And Evaluation Of Immediate-Release Tablets Of Cenobamate, Indo Am. J. P. Sci, 2025; 12(10).
REFERENCES:
1. Mahboob MBH, Tehseen R, Jamshaid M, Irfan B and Zulfiqar AS: Oral films: a comprehensive review International Current Pharmaceutical Journal 2016; 5(12): 111-17.
2. Sharma D, Singh M, Kumar D and Singh AG: Formulation development and evaluation of fast disintegrating tablet of Cetirizine hydrochloride: A novel drug delivery for pediatrics and geriatrics. Journal of Pharmaceutics 2014; 1-8.
3. Shilpa S, Kumar A and Garigeyi PG: Formulation and optimization of Clopidogrel bisulfate immediate release tablet. International Journal of Pharmaceutical, Chemical and Biological Sciences 2012; 2(1): 38-51.
4. Shailesh S, Gurjeet S and Gupta AG: Formulation design and optimization of mouth dissolving tablets of Domperidone using the sublimation technique. International Journal of Pharmaceutical Sciences 2010; 1(1): 128-36.
5. Jadhav SB, Mali AD, Rajeghadage SH and Bathe ARS: Formulation and evaluation of immediate release tablets of Imipramine hydrochloride. International Journal of Biomedical and Advance Research 2014; 5(11): 559.-65.
6. Patel N, Natarajan R and Rajendran NN: Formulation and evaluation of immediate release bilayer tablets of Telmisartan and Hydrochlorothiazide. International Journal of Pharmaceutical Sciences and Nanotechnology 2011; 4(3): 1477-82.
7. Verma K, Sharma PK, Dudhe R and Patro ASK: Formulation, design and development of Mifepristone immediate release tablet. International Journal of Pharma Sciences and Research 2014; 5(11): 760-69.
8. A Gupta, AK Mishra, V Gupta, P Bansal, R Singh, AK Singh, Review Article, Recent Trends of Fast Dissolving Tablet – An Overview of Formulation Technology, International Journal of Pharmaceutical & Biological Archives.2010; 1(1): 1 – 10.
9. Rathod VG, Kadam V, Jadhav SB, Zamiruddin M, Bharkad VB and Biradar SP: Immediate release drug delivery system: a review. World Journal of Pharmacy and Pharmaceutical Sciences 2014; 3(6): 545-58.
10. A Gupta, AK Mishra, V Gupta, P Bansal, R Singh, AK Singh, Review Article, Recent Trends of Fast Dissolving Tablet – An Overview of Formulation Technology, International Journal of Pharmaceutical & Biological Archives2010; 1(1): 1 – 10.
11. . Shaik A, Aruna R, Babu AMSS and Venkateswara RP: Immediate release drug delivery system-a review. International Journal of Research in Pharmaceutical and Nano Sciences 2013; 2(4): 448-58.
12. Sisodiya MH and Saudagar BAR: Review on immediate release drug delivery systems. World Journal of Pharmacy and Pharmaceutical Sciences 2018; 7(4): 539-61.
13. Mahida MV and Gupta MM: Immediate release tablet of antihypertensive drug Olmesartan medoxomile. Journal of Drug Delivery and Therapeutics 2013; 3(2): 186-95.
14. Sood R, Rathore MS, Sharma A, Thakur R, Chaudhari J and Soni V: Immediate release antihypertensive Valsartan oral tablet: a review. Journal of Scientific Research in Pharmacy 2012; 1(2): 20-26.
15. Sood R, Rathore MS, Sharma A, Thakur R, Chaudhari J and Soni V: Immediate release antihypertensive Valsartan oral tablet: a review. Journal of Scientific Research in Pharmacy 2012; 1(2): 20-26.
16. Pande V, Karale P, Goje P and Mahanavar S: An overview on emerging trends in immediate release tablet technologies. Austin Publishing Group 2016; 3(1): 1-8.
17. Neeraj B, Abhishek K, Abhilash C, Rubia C and Rajni B: A review on immediate release drug delivery system. International Research Journal of Pharmaceutical and Applied Sciences 2014; 4(1): 78-87.
18. Rajni D and Sandeep AK: Immediate release dosage forms: Thrust areas and challenges. International Journal of Current Advanced Research 2018; 7(5): 12550-555.
19. Solanki HK, Basuri T, Thakkar JH and Patel CA: Recent advances in granulation technology. International Journal of Pharmaceutical Sciences Review and Research 2010; 5(3): 48-54.
20. Muralidhar P, Bhargav E and Sowmya C: Novel techniques of granulation: A review. International Research Journal of Pharmacy 2016; 7(10): 8-13.
21. More SK and Wagh MP: Review on spray drying technology. International Journal of Pharmaceutical, Chemical and Biological Sciences 2014; 4(2): 219-225.
22. Vashisht V, Jain K, Kaur S and Mehra NK: Recent advances in granulation technologies. International Journal of Pharma Sciences 2015; 5(4): 1144-54.
23. Jannat E, Arif AA, Hasan MM, Zarziz AB and Rashid HA: Granulation techniques & its updated modules. The Pharma Innovation Journal 2016; 5(10): 134-41.
24. Suryawanshi AP, Shinkar DM and Saudagar RB: Granulation techniques. Asian Journal of Research in Pharmaceutical Sciences 2015; 5(4): 203-15.
25. Lavanya M, Gorantla N, Pawan R and Abdul AH: Foam granulation and advanced technique of granulation. World Journal of Pharmacy and Biotechnology 2016; 3(1): 56-59.
26. Rawat S, Derle DV, Fukte SR, Shinde PR and Parve BS: Superdisintegrants: an overview. World Journal of Pharmacy & Pharmaceutical Sciences 2014; 3(5): 263-78.
27. Nasir A, Gohar UF and Ahmad B: A review article on superdisintegrants. International Research Journal of Pharmaceutical Sciences 2017; 8: 01-011.
28. Bhowmik D, Chiranjib, Yadav J, Chandira RM and Sampath KKPL: Emerging trends of disintegrants used in formulation of solid dosage form. Scholars Research Library 2010; 2(1): 495-04.
29. Sharma SN and Sonawane RS: Role of superdisintegrants in immediate release tablets: a review. Journal of Pharmaceutical and BioSciences 2017; 5(1): 1-5.
30. Rakesh P And Gupta N: Superdisintegrants In The Development Of Orally Disintegrants Tablets: A Review. International Journal Of Pharmaceutical Sciences And Research 2011; 2(11): 2767-80.
31. Kaur V and Mehara N: A review on the importance of superdisintegrants on immediate release tablets. International Journal of Research and Scientific Innovation 2016; 3(2): 39-43.
32. Fathima N, Mamatha T, Qureshi HK, Anitha N and Rao JV: Drug-excipient interaction and its importance in dosage form development. Journal of Applied Pharmaceutical Science 2011; 1(6): 66-71.
33. Chaudhari SP and Patil PS: Pharmaceutical excipients: a review. International Journal of Advances in Pharmacy, Biology and Chemistry 2012; 1(1): 21-34.
34. Vemula SK, Paulos B and Kebamo S: Effect of combination of superdisintegrant on dissolution rate: Meclizine hydrochloride fast dissolving tablets. Science, Technology & Arts Research Journal 2015; 4(1): 124-28.
35. Reddy.L.H et al., “Fast dissolving drug delivery systems: A review of the literature , IJPS. , July 2002:331-336.
36. Jinjiang Li and, Xiaohui Mei, Applications of Cellulose and Cellulose Derivatives in Immediate Release Solid Dosage ACS Symposium Series,Vol.934Polysaccharides for Drug Delivery and Pharmaceutical Applications Chapter 2, pp 19-55.
37. A B Chinchawade, S L Jadhav, D D Gaikwad, Formulation and Evaluation of Immediate Release Tablet of Lercanidipine HCL. International Journal of Research in Engineering and Science (IJRES), Volume 11 Issue 9 ǁ September 2023.
38. Shweta Thakur, Ramakant Sharma, Shabnam Khan, Jeevan Patel and Rakesh Patel. Formulation and evaluation of immediate release tablet of Cisapride. World Journal of Biology Pharmacy and Health Sciences, 14(01), 2023.
39. Singh B, Sharma A, Chaudhary Amit, Saini Geetanjali, Vyas Manish. Design, Formulation, and In-vitro Evaluation of Immediate Release Tablet of Etoricoxib using Quality by Design Approach. Journal of Applied Pharmaceutical Sciences and Research; 6(1):25-33. 2023.
40. Muppavarapu Anusha and Vanitha K, Formulation and Evaluation of Immediate-Release Tablets of Edoxaban Tosylate. Int. J.Exp. Biomed. Res. 1(4): 177-190, 2022.
41. M. Lakshmi Prasanna, P. Prajna, P. Chinnari, P. Anusha, P.N.R. Sri Harshini and P.V.L.S. Ratna. formulation and evaluation of rivaroxaban immediate release tablets. IJRPC, 12(2), 129-138,2022.
42. Suresh Jadhav, Shankar Dhobale, Dushyant Gaikwad, Omkar Lohote, Harshad Padekar. Design, Formulation and Evaluation of Immediate Release Tablets of Hydrochlorthiazide. Bull. Env. Pharmacol. Life Sci., Vol 10 [2] January 2021.
43. Dr Y. Krishna Reddy, D. Kalpana. Formulation Development and Evaluation of Immediate Release Tablet Dosage form of Sorafenib Tosylate. Asian J. Pharm. Tech; 10(1):38-42 2020.
44. Mr. Patel Dhruv, Dr. Patel Upendra, Shukla Maitri, Mr. Bhimani Bhavin, Mr. Patel Ghanshyam. Formulation and Evaluation of Immediate Release Tablet of Simvastatin, Research Journal of Pharmacy and Technology, Volume: 13, Issue: 1, Year: 2020.
45. Arti Mohan, G. Sangeetha. Formulation and Evaluation of Immediate Release Film Coated Tablets of An Anticancer Drug (Dasatinib). Research J. Pharm. and Tech; 12(2):729-734.
46. 2019.
47. Remya P.N, Saraswathi.T.S, Sangeetha. S, Damodharan N, Kavitha.R. Formulation and Evaluation of Immediate Release Tablets of Acyclovir. J. Pharm. Sci. & Res. Vol. 8(11), 2016.