Volume : 12, Issue : 10, October – 2025
Title:
EVALUATION OF TRANSDERMAL GEL OF LISINOPRIL DIHYDRATES
Authors :
Chinthala Yashwanth Kumar *, T. Vijaya Kumari, dr. D. Venkata ramana.
Abstract :
Transdermal drug delivery has made an important contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. Various new technologies have been developed for the transdermal delivery of some important drugs. The goal of the present study was to formulate and evaluate the potential use of transfersomal vesicles as a transdermal drug delivery system for the poorly soluble drug, Lisinopril Dihydrate. It was investigated by encapsulating the drug in various transfersomal formulations composed of various ratios of tween-80 prepared by thin film hydration method. The prepared formulations were characterized for entrapment efficiency (EE %), drug content, in-vitro skin permeation studies.
The vesicles were spherical in structure as confirmed by Transmission Electron Microscopy. The EE% of Lisinopril Dihydrate in the vesicles was in the range of 87.16%. The result revealed that Lisinopril Dihydrate in all of the formulations was successfully entrapped with uniform drug content. The optimized Lisinopril Dihydrate -loaded transfersom was used to prepare Lisinopril Dihydrate -loaded transfersomal gel with the aid of HPMC K100 M, Eudragit L100 as the gelling agent. The Optimized Lisinopril Dihydrate -loaded transfersomal gel had a pH, Viscosity, Extrudability, Homogeneity, Drug Content, Spreadability and Ex vivo permeation studies. It is evident from this study that transfersomes are a promising prolonged delivery system for Lisinopril Dihydrate and have reasonably good stability characteristics. This research suggests that Lisinopril Dihydrate loaded transfersomes can be potentially used as a transdermal drug delivery system. According to this report, Transfersomal Gel is a promising long-term delivery mechanism for Lisinopril Dihydrate and has reasonably good stability. This study suggests that Transfersomal gel Lisinopril Dihydrate may be used as a transdermal drug delivery tool for fungal skin infections.
Key words: Lisinopril Dihydrate, Transfersomes, Soya phosphatidyl choline and Tween 80.
Cite This Article:
Please cite this article in press Chinthala Yashwanth Kumar et al., Design And Development Of Lovastatin Mouth Dissolving Tablets By Using Novel Super Disintegrants, Indo Am. J. P. Sci, 2025; 12(10).
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