Volume : 12, Issue : 10, October – 2025
Title:
FORMULATION AND IN VITRO EVALUATION OF IMMEDIATE RELEASETABLETS CONTAINING FEBUXOSTAT
Authors :
Atufa Nameera , Dr.Abdul Sayeed, Dr.Syed Areefulla Hussainy, Dr.FaizanSayeed
Abstract :
The present study focuses on the Formulation and inVitro Evaluation of Immediate Release tablets Containing Febuxostat, a xanthine oxidase inhibitor used in the treatment of hyperuricemia and gout. The primary objective was to enhance the dissolution rate and ensure rapid onset of action by incorporating various superdisintegrants. Immediate release tablets were formulated using different polymers including Sodium Starch Glycolate, Polyplasdone XL10, and Ac-Di-Sol in varying concentrations. A total of nine formulations (F1–F9) were prepared by direct compression method. Pre-compression and post- compression parameters such as angle of repose, bulk density, hardness, friability, disintegration time, and drug content were evaluated and found to be within acceptable limits as per IP specifications. Among all the formulations, F5, containing Polyplasdone XL10, exhibited the best performance with a drug release of 99.75% within 30 minutes, making it the optimized formulation. The study concludes that Polyplasdone XL10 is an effective superdisintegrant for the development of immediate release Febuxostat tablets, offering rapid disintegration and enhanced drug release profile.
Keywords: Febuxostat, Immediate Release Tablets
Cite This Article:
Please cite this article in press Atufa Nameera et al., Formulation And In Vitro Evaluation Of Immediate Releasetablets Containing Febuxostat , Indo Am. J. P. Sci, 2025; 12(10).
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