Volume : 12, Issue : 11, November – 2025
Title:
AN OVERVIEW AND MEDICINAL PLANT USED IN THE TREATMENT OF ROSACEA
Authors :
Miss Poonam G Pophale, Aditya S Kakad,Dr. Swati P Deshmukh
Abstract :
Rosacea is a long-term inflammatory skin condition that primarily affects the central area of the face. It is marked by recurring facial flushing, persistent redness, visible blood vessels (telangiectasia), inflammatory bumps or pustules, thickened skin changes, and sometimes eye involvement. Although the exact cause remains unclear, rosacea is believed to result from a combination of factors, including immune system imbalance, neurovascular irregularities, and genetic as well as environmental influences.
Clinically, rosacea is divided into four main subtypes based on its dominant features: erythematotelangiectatic, papulopustular, phymatous, and ocular. Advances in understanding its underlying mechanisms have led to a variety of treatment options. These include topical agents such as azelaic acid, metronidazole, benzoyl peroxide, clindamycin, erythromycin, and newer formulations like brimonidine, oxymetazoline, ivermectin, and minocycline. Systemic therapies may involve oral antibiotics, isotretinoin, non-selective beta-blockers, or alpha-2 adrenergic agonists. Additionally, light- and laser-based treatments, along with emerging therapeutic strategies, offer further management possibilities. The purpose of this review is to summarize the current knowledge of rosacea’s pathophysiology and highlight targeted treatment approaches for each subtype
Cite This Article:
Please cite this article in press Poonam Gajanan Pophale et al., An Overview And Medicinal Plant Used In The Treatment Of Rosacea, Indo Am. J. P. Sci, 2025; 12(11).
REFERENCES:
1. Gether L, Overgaard LK, Egeberg A, Thyssen JP. Incidence and prevalence of rosacea: a systematic review and meta‐analysis. British Journal of Dermatology. 2018 Aug 1;179(2):282-9.
2. Zhang H, Tang K, Wang Y, Fang R, Sun Q. Rosacea treatment: review and update. Dermatology and therapy. 2021 Feb;11(1):13-24.
3. Wang L, Xie X, Ke B, Huang W, Jiang X, He G. Recent advances on endogenous gasotransmitters in inflammatory dermatological disorders. Journal of Advanced Research. 2022 May 1;38:261-74.
4. Rhee MK, Yeu E, Barnett M, Rapuano CJ, Dhaliwal DK, Nichols KK, Karpecki P, Mah FS, Chan A, Mun J, Gaddie IB. Demodex blepharitis: a comprehensive review of the disease, current management, and emerging therapies. Eye & contact lens. 2023 Aug 1;49(8):311-8.
5. Zhou DD, Li J, Xiong RG, Saimaiti A, Huang SY, Wu SX, Yang ZJ, Shang A, Zhao CN, Gan RY, Li HB. Bioactive compounds, health benefits and food applications of grape. Foods. 2022 Sep 7;11(18):2755.
6. Gandolfi S, Lupon E, Varin A, Coste A, Sallerin B, Boyer C, Berkane Y, Chaput B. Evolution of cell therapies derived from adipose tissue: historical perspectives, current development trends and future directions. Biology Direct. 2025 Aug 27;20(1):95.
7. Akbari B, Baghaei‐Yazdi N, Bahmaie M, Mahdavi Abhari F. The role of plant‐derived natural antioxidants in reduction of oxidative stress. BioFactors. 2022 May;48(3):611-33.
8. Lonardo A, Mantovani A, Petta S, Carraro A, Byrne CD, Targher G. Metabolic mechanisms for and treatment of NAFLD or NASH occurring after liver transplantation. Nature Reviews Endocrinology. 2022 Oct;18(10):638-50.
9. Kallis PJ, Price A, Dosal JR, Nichols AJ, Keri J. A Biologically Based Approach to Acne and Rosacea. Journal of Drugs in Dermatology: JDD. 2018 Jun 1;17(6):611-7.
10. Al-Niaimi F, Chiang NY. Topical vitamin C and the skin: mechanisms of action and clinical applications. The Journal of clinical and aesthetic dermatology. 2017 Jul 1;10(7):14.
11. DePhillipo NN, Aman ZS, Kennedy MI, Begley JP, Moatshe G, LaPrade RF. Efficacy of vitamin C supplementation on collagen synthesis and oxidative stress after musculoskeletal injuries: a systematic review. Orthopaedic journal of sports medicine. 2018 Oct 19;6(10):2325967118804544.
12. Carlin RB, Carlin CS. Topical vitamin C preparation reduces erythema of rosacea. COSMETIC DERMATOLOGY-CEDAR KNOLLS-. 2001 Jan 1;14(2):35-40.
13. Mousavi S, Bereswill S, Heimesaat MM. Immunomodulatory and antimicrobial effects of vitamin C. European Journal of Microbiology and Immunology. 2019 Sep;9(3):73-9.
14. Searle T, Ali FR, Al-Niaimi F. The versatility of azelaic acid in dermatology. Journal of Dermatological Treatment. 2022 Feb 17;33(2):722-32.
15. Draelos ZD, Elewski BE, Harper JC, Sand M, Staedtler G, Nkulikiyinka R, Shakery K. A phase 3 randomized, double-blind, vehicle-controlled trial of azelaic acid foam 15% in the treatment of papulopustular rosacea. Cutis. 2015 Jul 1;96(1):54-61.
16. Elewski BE, Fleischer AB, Pariser DM. A comparison of 15% azelaic acid gel and 0.75% metronidazole gel in the topical treatment of papulopustular rosacea: results of a randomized trial. Archives of dermatology. 2003 Nov 1;139(11):1444-50.
17. Gupta AK, Gover MD. Azelaic acid (15% gel) in the treatment of acne rosacea. International journal of Dermatology. 2007 May;46(5):533-8.
18. Gupta M, Mahajan VK, Mehta KS, Chauhan PS. Zinc therapy in dermatology: a review. Dermatology research and practice. 2014;2014(1):709152.
19. Prasad AS. Zinc: an antioxidant and anti-inflammatory agent: role of zinc in degenerative disorders of aging. Journal of Trace Elements in Medicine and Biology. 2014 Oct 1;28(4):364-71.
20. Sharquie KE, Najim RA, Al‐Salman HN. Oral zinc sulfate in the treatment of rosacea: a double‐blind, placebo‐controlled study. International journal of dermatology. 2006 Jul;45(7):857-61.
21. Sharquie KE, Noaimi AA, Al-Hashimy SA, Al-Salih MM. Therapeutic evalua
22. tion of 2% tea lotion in comparison with 5% zinc sulfate solution in the treatment of acne rosacea. Journal of Cosmetics, Dermatological Sciences and Applications. 2014 Jan 23;2014.
23. Bahraini P, Rajabi M, Mansouri P, Sarafian G, Chalangari R, Azizian Z. Turmeric tonic as a treatment in scalp psoriasis: A randomized pl inacebo‐control clinical trial. Journal of Cosmetic Dermatology. 2018 Jun;17(3):461-6.
24. Zhang S, Wang J, Liu L, Sun X, Zhou Y, Chen S, Lu Y, Cai X, Hu M, Yan G, Miao X. Efficacy and safety of curcumin in psoriasis: preclinical and clinical evidence and possible mechanisms. Frontiers in pharmacology. 2022 Aug 29;13:903160.
25. Barbalho SM, de Sousa Gonzaga HF, de Souza GA, de Alvares Goulart R, de Sousa Gonzaga ML, de Alvarez Rezende B. Dermatological effects of Curcuma species: a systematic review. Clinical and experimental dermatology. 2021 Jul 1;46(5):825-33.
26. Sharifi-Rad J, Rayess YE, Rizk AA, Sadaka C, Zgheib R, Zam W, Sestito S, Rapposelli S, Neffe- Skocińska K, Zielińska D, Salehi B. Turmeric and its major compound curcumin on health: bioactive effects and safety profiles for food, pharmaceutical, biotechnological and medicinal applications. Frontiers in pharmacology. 2020 Sep 15;11:550909.