Volume : 12, Issue : 11, November – 2025

Title:

REVIEW ON HERBAL ORAL ANTI-ULCER SYRUP

Authors :

Chaitali Sanjiv Gawai*, Prerna Ravindra kharat, Shaikh M. Zainuddin, Priyanka Deshmukh, Dr. Kavita Kulkarni

Abstract :

Peptic ulcer disease remains a prevalent gastrointestinal disorder often associated with gastric acid imbalance, oxidative stress, Helicobacter pylori infection, and mucosal damage. Conventional synthetic anti-ulcer drugs provide symptomatic relief but may lead to adverse effects with long-term use. Increasing interest in herbal medicine has encouraged the development of oral anti-ulcer syrups prepared from plant-based ingredients with proven gastro protective potential. This review summarizes the therapeutic roles of selected medicinal plants such as Glycyrrhiza glabra, Aloe vera, Zingiber officinal, Ocimum sanctum, and Mentha piperita, which are commonly incorporated in herbal anti-ulcer formulations. Their phytoconstituents—flavonoids, tannins, saponins, mucilage, and essential oils—exhibit anti-secretory, antioxidant, anti-inflammatory, and mucosal-protective activities. The review also highlights the mechanisms of action, safety profile, dosage considerations, and formulation advantages of herbal syrups as a patient-friendly dosage form. Overall, herbal oral anti-ulcer syrups represent a promising complementary approach for managing gastric ulcers with fewer side effects, supporting their potential use in future phytopharmaceutical development.
KEYWORDS: Herbal, Oral, Anti-Ulcer Syrup, Glycyrrhiza Glabra, Anti-Ulcer, Sugar etc.

Cite This Article:

Please cite this article in press Chaitali Sanjiv Gawai et al., Review On Herbal Oral Anti-Ulcer Syrup, Indo Am. J. P. Sci, 2025; 12(11).

REFERENCES:

1. Ramesh R, Patel R. India’s opportunity. Curr Sci. 2004;86(1):37-41.
2. Das S, Shankar R, Mantry S. Physical Pharmaceutics. 3rd ed. Pune: Nirali Prakashan; 2019. p. 52-53.
3. Garg K, Paul A, Dalal M, Soni H. Evaluation of acid-neutralizing and antiulcer potential of a polyherbal formulation. Int J Herb Med. 2020;8(5):33-41.
4. Fendrick M, Forsch R. Peptic Ulcer Disease: Guidelines for Clinical Care. University of Michigan Health System; 2005.
5. Rasve V, Chakraborty AK, Jain SK, Vengurlekar S. Study of phytochemical profiling and in vitro antioxidant properties of ethanolic extract of Clematis triloba. Eur Chem Bull. 2022;11(12):2658-77.
6. Bhateja S, Arora G. Therapeutic benefits of Holy Basil in general and oral medicine: A review. Int J Res Ayurveda Pharm. 2012;3(2):293-297.
7. Shafiya R, Rajkumari K, Sofi SA, Nadia B. Citrus peel as a source of functional ingredient: A review. J Saudi Soc Agric Sci. 2015;14(2):168-175.
8. Gadekar R, Singour PK, Chaurasiya PK, Pawar RS, Patil UK. A review on potential of some medicinal plants as antiulcer agents. Pharmacogn Rev. 2010;4(8):107-114.
9. Sun XB, Matsumoto T, Yamada H. Anti-ulcer activity and mechanism of action of the polysaccharide fraction from Panax ginseng leaves. Planta Med. 1992;58(5):432-435.
10. Deb Roy S, Chakraborty J, Shil D, Das S, Begum N. Herbs used in peptic ulcer: A comprehensive review. J Drug Deliv Ther. 2020;10(4):130-137.
11. Malfertheiner P, Chan FK, McColl KE. Peptic ulcer disease. Lancet. 2009;374(9699):1449-1461.
12. Rasve VR, Chakraborty AK, Jadhav NY. Diabetes mellitus: A review. World J Pharm Pharm Sci. 2021;10(4):961-74.
13. Wallace JL. Prostaglandins, NSAIDs, and gastric mucosal protection. Physiol Rev. 2008;88(4):1547-1565.
14. Goel RK, Sairam K. Anti-ulcer drugs from indigenous sources with emphasis on Musa sapientum, Tamrabhasma, Asparagus racemosus and Zingiber officinale. Indian J Pharmacol. 2002;34(2):100-110.
15. Bandyopadhyay U, Biswas K, Chattopadhyay I, Banerjee RK. Turmeric and curcumin: Biological actions and medicinal applications. Curr Sci. 2007;92(10):1337-1345.
16. Tripathi KD. Essentials of Medical Pharmacology. 8th ed. New Delhi: Jaypee Brothers; 2019. p. 695-702.
17. Dharmani P, Palit G. Exploring Indian medicinal plants for antiulcer activity. Indian J Pharmacol. 2003;35:95-103.
18. Chatterjee A, Pakrashi SC. The Treatise on Indian Medicinal Plants. Vol 2. New Delhi: CSIR; 2001.
19. Tandon R, Khanna N. Gastric ulcer protective activity of Ocimum sanctum in rats. J Ethnopharmacol. 1997;57(1):77-82.
20. Sharma A, Bhatia S, Khajuria A. Anti-inflammatory and antiulcer properties of Terminalia chebula fruit. Indian J Exp Biol. 2011;49(11):875-882.
21. Borrelli F, Izzo AA. The plant kingdom as a source of anti-ulcer remedies. Phytother Res. 2000;14(8):581-591.