Volume : 12, Issue : 11, November – 2025
Title:
DEVELOPMENT OF RP-HPLC METHOD FOR THE QUANTITATIVE ANALYSIS OF NORFLOXACIN AND ORNIDAZOLE PURE FORM AND IT’S APPLICATION IN EVALUATION OF MARKETED PREPARATIONS
Authors :
Ganji Navya*, Dr. CH Pavani, Dr. Bigala Rajkamal
Abstract :
A new simple, accurate, economic, rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Norfloxacin and Ornidazole, in its pure form as well as in pharmaceutical dosage form. Chromatography was carried out on X bridge C18 (4.6×150mm) 5 µ column using a mixture of Methanol: Phosphate Buffer pH-3.6 (30:70v/v) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 260nm. The retention time of the Norfloxacin and Ornidazole was 2.669, 3.855±0.02min respectively. The method produce linear responses in the concentration range of 10-50µg/ml of Norfloxacin and 10-50µg/ml of Ornidazole. The method precision for the determination of assay was below 2.0%RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.
Keywords: Norfloxacin and Ornidazole, RP-HPLC, Validation.
Cite This Article:
Please cite this article in press Ganji Navya et al., Development Of Rp-Hplc Method For The Quantitative Analysis Of Norfloxacin And Ornidazole Pure Form And It’s Application In Evaluation Of Marketed Preparations, Indo Am. J. P. Sci, 2025; 12(11).
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