Volume : 12, Issue : 11, November – 2025
Title:
A REVIEW ON NANOFORMULATION OF PLANT BASED NATURAL PRODUCTS TARGETING IMPROVED β- CELL FUNCTION IN DIABETES MELLITUS
Authors :
Reshma B V
Abstract :
Herbal remedies are used to manage type 2 diabetes mellitus (type 2 DM) as the sole treatment or as a complementary therapy. Limitations of herbal remedies, such as poor stability and limited absorption, impede their development as therapeutic agents, which could be overcome by nanoformulations.This review attempts to summarize the studies reported between 2009 and 2020 in the development of medicinal plant-based nanoformulations for the management of type 2 DM, discuss formulation methods, mechanisms of action, and identify gaps in the literature to conduct future research on nanoparticle-based herbal treatment options targeting type 2 DM.
Nanoformulations of plant-based natural products improve diabetes management by increasing the bioavailability of plant compounds, which can then improve glycemic control, enhance insulin sensitivity, and protect pancreatic beta-cells. Nanotechnology creates formulations like polymeric nanoparticles and liposomes that encapsulate active compounds, leading to better stability, solubility, and targeted delivery compared to the natural plant extracts alone. To retrieve articles published between January 2009 and December 2020, the electronic databases PubMed, Science Direct, and Google Scholar were searched with the keywords nanoparticle, plant, and diabetes in the entire text. Peer-reviewed research articles on herbal nanoformulations published in English-language based on in vitro and/or in vivo models of type 2 DM and/or its complications were included.
Keywords: herbal remedies; inorganic nanoformulations; lipid-based nanoformulations; polymeric nanoformulations; type 2 diabetes mellitus.
Cite This Article:
Please cite this article in press Reshma B V ., a review on nanoformulation of plant based natural products targeting improved β- cell function in diabetes mellitus, Indo Am. J. P. Sci, 2025; 12(11).
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