Volume : 12, Issue : 11, November – 2025
Title:
EFFECT OF HIGH-DOSE VITAMIN D ON ASTHMA CONTROL AND LUNG FUNCTION: A RANDOMIZED CONTROLLED TRIAL
Authors :
Dr Maria shaikh, Dr. Hawaida Khan, Muhammad Fahad Khaliq , Behram Khan
Abstract :
Background: Asthma had remained a prevalent chronic inflammatory airway disorder characterized by recurrent episodes of wheezing, breathlessness, and reduced lung function. Despite the availability of standard therapeutic interventions, many patients had continued to experience suboptimal symptom control. Vitamin D deficiency had increasingly been recognized as a potential modifiable factor influencing asthma severity and respiratory function. High-dose vitamin D supplementation had been hypothesized to improve asthma outcomes by modulating immune responses and enhancing airway stability.
Aim: This study had aimed to evaluate the effect of high-dose vitamin D supplementation on asthma control and lung function among adult patients with moderate persistent asthma.
Methods: This randomized controlled trial had been conducted at Mayo Hospital, Lahore, from October 2024 to September 2025. The study population had comprised 90 adult patients aged 18–55 years with clinically diagnosed moderate persistent asthma. Participants had been randomly assigned into two equal groups: the intervention group, which had received high-dose vitamin D (50,000 IU weekly for 12 weeks), and the control group, which had received a placebo in addition to standard asthma therapy. Asthma control had been assessed using the Asthma Control Test (ACT) scores, while lung function parameters—Forced Expiratory Volume in one second (FEV₁) and Peak Expiratory Flow Rate (PEFR)—had been measured using standardized spirometry protocols at baseline and after 12 weeks of follow-up. Data collection had been performed by trained respiratory technicians, and statistical analysis had been carried out using independent t-tests and paired comparisons.
Results: The intervention group had demonstrated a significant improvement in ACT scores compared to baseline, with a mean increase of 5.2 ± 1.8 points, whereas the control group had shown a modest improvement of 1.6 ± 1.1 points. Similarly, FEV₁ values had improved by 12.4% in the intervention group compared to 4.1% in the control group. PEFR had also increased substantially in the vitamin D group by 45.6 L/min, compared to 12.3 L/min in the placebo group. The differences between groups had been statistically significant (p < 0.05). No major adverse events related to vitamin D supplementation had been reported.
Conclusion: The study had concluded that high-dose vitamin D supplementation significantly improved asthma control and lung function among adults with moderate persistent asthma. Incorporating vitamin D supplementation as an adjunct to standard asthma therapy had the potential to enhance clinical outcomes, particularly in populations with underlying vitamin D insufficiency.
Keywords: Asthma, Vitamin D, Lung Function, Asthma Control Test, Randomized Controlled Trial, Respiratory Health.
Cite This Article:
Please cite this article in press Dr Maria shaikh et al., Effect Of High-Dose Vitamin D On Asthma Control And Lung Function: A Randomized Controlled Trial, Indo Am. J. P. Sci, 2025; 12(11).
REFERENCES:
1. Alansari K, Davidson BL, Holick MF. A Randomized Comparison of IM High-Dose versus Oral Maintenance Vitamin D to Prevent Severe Exacerbations in Deficient/Insufficient Asthmatic Children. Journal of Allergy and Clinical Immunology: Global. 2025 May 21:100497.
2. Krasowski R, Kamińska K, Głodek K, Ostrowska J, Zajda K, Pawliczak R, Kleniewska P. The therapeutic potential of vitamin D supplementation in asthma. Pharmacological Reports. 2025 May 20:1-5.
3. Irfan M, Ullah M, Ansari A, Iqbal N. Vitamin D and chronic respiratory diseases: a complex relationship. InThe Impact of Vitamin D on Health and Disease 2026 Jan 1 (pp. 165-190). Elsevier.
4. Songnuy T, Ninla-Aesong P, Thairach P, Thok-Ngaen J. Effectiveness of an antioxidant-rich diet on childhood asthma outcomes: A randomized controlled trial. BMC nutrition. 2025 Dec;11(1):1-2.
5. Patchen BK, Best CM, Boiteau J, Solvik BS, Vonderschmidt A, Xu J, Cohen RT, Cassano PA. Vitamin D supplementation in pregnant or breastfeeding women or young children for preventing asthma. Cochrane Database of Systematic Reviews. 2025(8).
6. Salas AA, Argent T, Jeffcoat S, Tucker M, Ashraf AP, Travers CP. Early vitamin D supplementation in infants born extremely preterm and fed human milk: a randomized controlled trial. The Journal of Pediatrics. 2025 Jul 24:114754.
7. Devulapalli CS. Vitamin D supplements reduce risk of viral upper respiratory infections in children with lower concentrations. Acta Paediatrica. 2025 May;114(5):816-22.
8. Saleem J, Zakar R, Butt MS, Kaleem R, Chaudhary A, Chandna J, Jolliffe DA, Piper J, Abbas Z, Tang JC, Fraser WD. High-dose vitamin D3 to improve outcomes in the convalescent phase of complicated severe acute malnutrition in Pakistan: a double-blind randomised controlled trial (ViDiSAM). Nature communications. 2025 Mar 15;16(1):2554.
9. Ali M, Mortensen MS, Bæk O, Brustad N, Wang T, Chen L, Kim M, Pedersen CE, Lawley TD, Pasias A, Sedzinski J. Effects of n-3 Long-Chain Polyunsaturated Fatty Acid and Vitamin D Supplementation on Transcriptional Profiles of Human Lung Organoids. Metabolites. 2025 Oct 14;15(10):670.
10. Mohammed SH, Hendy RM. Assessing the relationship between Vitamin D and asthma severity. Benha Medical Journal. 2025 Nov 1.
11. Jolliffe DA, Camargo CA, Sluyter JD, Aglipay M, Aloia JF, Bergman P, Bischoff-Ferrari HA, Borzutzky A, Bubes VY, Damsgaard CT, Ducharme FM. Vitamin D supplementation to prevent acute respiratory infections: systematic review and meta-analysis of stratified aggregate data. The Lancet Diabetes & Endocrinology. 2025 Apr 1;13(4):307-20.
12. Jolliffe D, Brustad N, Chawes B, Cooper C, D’Angelo S, Harvey N, Litonjua AA, Moon RJ, Morris SK, Sluyter JD, Weiss ST. Maternal Vitamin D Supplementation During Pregnancy to Prevent Acute Respiratory Infections in Offspring: Systematic Review and Meta-Analysis of Stratified Aggregate Data from Randomised Controlled Trials. Available at SSRN 5246534.
13. Halilović D, Nurkić J, Trnačević S, Nurkić M, Halilović E, Mujarić E. Correlation of vitamin D serum level and quality of life in asthma patients. Medicinski Glasnik. 2025 Feb 1;22(1).
14. Goswami C, Law S, Zhang H, Park H, Maheta B, Arnott K, Hsu M, Truong K, Sheffield M, Iqbal Z, Limanon C. Are there prophylactic effects of vitamin D among healthier adult patients? A systematic review of randomized controlled trials. BMC nutrition. 2025 Jul 4;11(1):118.
15. Ramniklal CK, Kumar AS, Yadav VK, Prasad VY, Tiwari A, Kumar M, Sharma M, Dev SK. Roles of Minerals and Micronutrients in Respiratory and Pulmonary Diseases. InNutraceuticals in Respiratory and Pulmonary Diseases 2026 (pp. 127-145). Apple Academic Press.