111.Issue 11 november 25 - INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES

Volume : 12, Issue : 11, November – 2025

Title:

ADVANCES IN ORAL CONTROLLED RELEASE DRUG DELIVERY SYSTEM

Authors :

Vaishnavi Rajesh Khanzode ,Mr. Avesh Sumar

Abstract :

Oral controlled release drug delivery systems (CRDDS) represent a major advancement in pharmaceutical technology, designed to improve therapeutic effectiveness, increase patient adherence, and reduce adverse effects. In contrast to traditional dosage forms, CRDDS deliver drugs at a consistent rate, ensuring stable drug levels in the bloodstream over a prolonged duration. Recent innovations in this area encompass new polymeric matrices, osmotic pump mechanisms, floating drug delivery systems, mucoadhesive formulations, and nanoparticle-based delivery vehicles. The integration of biodegradable polymers, hydrogels, and nanotechnology has allowed for greater control over drug release dynamics and targeted delivery. Additionally, 3D printing and microfabrication technologies are being utilized to develop customizable oral dosage forms with tailored release profiles. These advancements not only enhance treatment outcomes but also expand the potential for delivering drugs with low solubility and instability. Overall, the evolution of oral controlled release systems is transforming drug delivery science, supporting the development of personalized and effective oral therapies.
Keywords: Oral drug delivery, controlled release, polymeric systems, nanotechnology, mucoadhesive, osmotic pump, 3D

Cite This Article:

Please cite this article in press Vaishnavi Rajesh Khanzode et al., Advances In Oral Controlled Release Drug Delivery System, Indo Am. J. P. Sci, 2025; 12(11).

REFERENCES:

1. Robinson, J. R., & Lee, V. H. L. (Eds.). (1987). Controlled Drug Delivery: Fundamentals and Applications (2nd ed.). Marcel Dekker.
2. Brahmankar, D. M., & Jaiswal, S. B. (2009). Biopharmaceutics and Pharmacokinetics: A Treatise (2nd ed.).
3. Vallabh Prakashan. Siepmann, J., & Peppas, N. A. (2012). Modeling of drug release from delivery systems. Advanced Drug Delivery Reviews, 64, 163–174.
4. Stroppolo, A. et al. (2021). Stimuli-responsive drug delivery systems: From fundamentals to biomedical applications. Advanced Drug Delivery Reviews, 176, 113864.
5. Allen, L. V., Ansel, H. C. (2014). Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems (10th ed.). Lippincott Williams & Wilkins.
6. Siepmann, J., & Siepmann, F. (2008). Mathematical modeling of drug delivery. International Journal of Pharmaceutics, 364(2), 328–343.
7. Aulton, M. E., & Taylor, K. (2017). Aulton’s Pharmaceutics: The Design and Manufacture of Medicines (5th ed.). Elsevier.
8. Tangde, S., Gavhane, Y. N., & Saboo, S. (2021). Sustained release matrix type drug delivery systems: A review. International Journal of Creative Research Thoughts (IJCRT), 9(3), 3965–3980.
9. Raghavendra Rao, N. G., Prasanna Raj, K. R., & Nayak, B. S. (2013). Review on matrix tablet as sustained release. International Journal of Pharmaceutical Research & Allied Sciences, 2(3), 1–17.
10. Karna, S., Chaturvedi, S., Agrawal, V., & Alim, M. (2015). Formulation approaches for sustained release dosage forms: A review. Asian Journal of Pharmaceutical and Clinical Research, 8(5), 46–53. Get smarter responses, upload files and images, and more.
11. Mamidala, R., Ramana, V., Sandeep, G., Lingam, M., Gannu, R., & Yamsani, M. (2009). Factors Influencing the Design and Performance of Oral Sustained/Controlled Release Dosage Forms. International Journal of Pharmaceutical Sciences and Nanotechnology, 2(3), 583–596.
12. Jadhav, R., Bhui, B., Shelake, A., Rokade, A., Panche, A. (2024). A Comprehensive Review of Controlled Drug Delivery System. Journal of Emerging Technologies and Innovative Research (JETIR), 11(2), 307–326.
13. Sree Neetha, D., Reddy, S. M., & Vijetha, A. K. (2024). A Review on Developments in Controlled Release Drug Delivery Systems. International Journal of Research Publication and Reviews, 5(3), 5894–5900.
14. Mandhar, P., & Joshi, G. (2015). Development of Sustained Release Drug Delivery System: A Review. Asian Pacific Journal of Health Sciences, 2(1), 179–185.
15. Prakash Rao, H. A., Iswariya, V. T., Lokeswara Babu, V., & Srinivasa Rao, A. (2014). A Review on Controlled Drug Delivery System. International Journal of Pharmacy, 4(3), 275–282.
16. Patel, V., Jadon, A., Jain, P., Khare, B., Thakur, B., Khan, R., Ray, D., & Jain, A. (2022). Controlled Drug Delivery Systems: An Overview on Advances and New Technologies. World Journal of Pharmaceutical and Life Science (WJPLS), 8(12),
17. Mahale, B., Pimpale, B., Tadavi, S., & Patil, S. (2023). Anatomization on Controlled Drug Delivery System. STM Journals, 10(3), 21–29.
18. Saha, P., & Das, P. (2017). Advances in Controlled Release Technology in Pharmaceuticals: A Review. World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS), 6(9), 2070–2084.
19. Patil, S. S., Patel, N. D., Rane, B., Gujrathi, N., & Pawar, S. (2014). A Review on Control Drug Delivery System. International Journal of Pharmaceutical, Chemical and Biological Sciences (IJPCBS), 4(3), 529–536.
20. Sanapa, V., Vadak, S., & Pande, V. (2020). A Review on Extended-Release Drug Delivery System and Multiparticulate System. Journal of Emerging Technologies and Innovative Research (JETIR), 7(4), 1273–1287.
21. Kube, R. S., Kadam, V. S., Shendarkar, G. R., Jadhav, S. B., & Bharkad, V. B. (2015). Sustained Release Drug Delivery System: Review. Indian Journal of Research in Pharmacy and Biotechnology, 3(3), 246–251.
22. Shah, S., Shah, P., Patel, M., & Patel, M. (2015). A Review on Extended-Release Drug Delivery System and Multiparticulate System. World Journal of Pharmaceutical Research (WJPR), 4(8), 724–747.
23. Shirbhate, M., Bondhare, N., Ade, P., & Jangale, S. (2023). A Review on Sustained Release Drug Delivery System. International Journal of Novel Research and Development (IJNRD), 8(4), 50–60.
24. Prakash, D., Kumar, R., & Malviya, R. (2022). Novel Drug Delivery Carrier System: A Review. International Journal of Creative Research Thoughts (IJCRT), 10(9), 218– 228.
25. Sampath Kumar, P. K., Bhowmik, D., Srivastava, S., Paswan, S., & Dutta, S. A. (2012). Sustained Release Drug Delivery System Potential. The Pharma Innovation, 1(2), 48– 60.
26. Swarnalatha Mary, K., Iswariya, T. V., Banoth, A., Bhandari, S., Shirisha, R., & Ramarao, T. (2024). A Comprehensive Review of Controlled Drug Release Delivery Systems: Current Status and Future Directions. International Journal of Research Publication and Reviews (IJRPR), 5(6), 3684–3690.
27. Shelke, J., Gaikwad, V., & Wamane, V. (2023). A Review on Matrix Drug Delivery System. International Journal of Research Publication and Reviews (IJRPR), 3(6), 2639–2645.
28. Singh, A., Gupta, D., & Singh, S. (2022). Modified Release Drug Delivery System: Concept and System Design of Rate-Controlled Drug Delivery System. EPRA International Journal of Multidisciplinary Research (IJMR), 8(4), 145–149.
29. Patel, V., Jadon, A., Jain, P., Khare, B., Thakur, B., Khan, R., Ray, D., & Jain, A. (2022). Controlled Drug Delivery Systems: An Overview on Advances and New Technologies. World Journal of Pharmaceutical and Life Science (WJPLS), 8(12), 8592.
30. Mal, N., Bhunia, A., & Mahanti, B. (2024). A Comprehensive Overview of Controlled Drug Delivery System. World Journal of Pharmaceutical and Medical Research (WJPMR), 10(6), 316–327.
31. Tiwari, R. (2016). Controlled Release Drug Formulation in Pharmaceuticals: A Study on Their Application and Properties. World Journal of Pharmaceutical Research (WJPR), 5(2), 1704–1720.
32. Patil, S., & Agnihotri, J. (2022). Sustained and Controlled Drug Delivery System: A Review. International Journal of Pharmacy & Pharmaceutical Research, 23(4), 258– 282.
33. Vyas, S. P., & Khar, R. K. (2002). Controlled drug delivery: Concepts and advances (1st ed., pp. 156–189). Vallabh Prakashan.
34. Chien, Y. W. (n.d.). Novel drug delivery system (Vol. 50). [Publisher not specified].
35. Allen, L. V., Popovich, G. N., & Ansel, H. C. (2004). Ansel’s pharmaceutical dosage forms and drug delivery systems (8th ed., pp. 260–263). [Publisher not specified].
36. Patrick, J. S. (1991). Martin’s physical pharmacy and pharmaceutical sciences (3rd ed., pp. 512–519). Varghese Publishing House.
37. Kar, R. K., Mohapatra, S., & Barik, B. B. (2009). Design and characterization of controlled release matrix tablets of Zidovudine. Asian Journal of Pharmaceutical and Clinical Research, 2(2), 54–56.
38. Lachman, L., Liberman, H. A., & Kanig, J. L. (1987). The theory and practice of industrial pharmacy (3rd ed.). Varghese Publishing House. Bombay.
39. Jain, N. K. (1997). Controlled and novel drug delivery (pp. 1–25). CBS Publisher and Distribution.
40. Venkataraman, D. S. N., Chester, A., & Kleiner, L. (2000). An overview of controlled release systems. In Handbook of pharmaceutical controlled release technology (pp. 1– 30). Marcel Dekker Inc.
41. Gupta, S., Singh, R. P., Sharma, R., Kalyanwat, R., & Lokwani, P. (2011). Osmotic pumps: A review. International Journal of Comprehensive Pharmacy, 6, 1–8.
42. Robinson, J. R., & Lee, V. H. (1987). Controlled drug delivery (2nd ed., pp. 4–15). Marcel Dekker.
43. Kamboj, S., & Gupta, G. D. (2009). Matrix tablets: An important tool for oral controlled release dosage form. Pharmainfo.net, 7, 1–9.
44. Bechgaard, H., & Nielsen, G. H. (1978). Controlled release multiple units and single unit dosage. Drug Development and Industrial Pharmacy, 4, 53–67. https://doi.org/10.3109/03639047809055639
45. Wise, D. L. (2002). Handbook of pharmaceutical controlled release technology (pp. 432–460). Marcel Dekker Inc.
46. Gibaldi, M. (1984). Biopharmaceutics and clinical pharmacokinetics (3rd ed., p. 178). Lea & Febiger.
47. Heilmann, K. (1984). Therapeutics systems rate controlled drug delivery: Concept and development (2nd ed.). Georg Thieme Verlag.
48. Conaghey, O. M., Corish, J., & Corrigan, O. I. (1998). Iontophoretically assisted in vitro membrane transport of nicotine from a hydrogel containing ion exchange resin. International Journal of Pharmaceutics, 170, 225–225. https://doi.org/10.1016/s0378- 5173(98)00144-6
49. Mahore, J. G., Wadher, J., & Umekar, M. J., Bhoyar, P. K. (2010). Ion exchange resins: Pharmaceutical application and recent advancement. International Journal of Pharmaceutical Science Review and Research, 1(2), 8–13.
50. Ali, J., Khar, R. K., & Ahuja, A. (2009). Dosage form design (4th ed., pp. 181–194). Birla Publication Pvt. Ltd
51. Cristina, M., Aranzazu, Z., & Jose, M. L. (2011). Review: Critical factors in the release of drugs from sustained release hydrophilic matrices. International Journal of Research in Ayurveda and Pharmacy, 21, 1701–1708.
52. Herbig, S. M., Cardial, J. R., Korsmeyer, R. W., & Smith, K. L. (1995). Asymmetric membrane tablet coating for osmotic drug delivery. Journal of Controlled Release, 35, 127–136. https://doi.org/10.1016/0168-3659(95)00028-7
53. Gupta, R. N., Gupta, R., Basniwal, P. K., & Rathore, G. S. (2009). Osmotically controlled oral drug delivery systems: A review. International Journal of Pharmaceutical Sciences, 1(2), 75–269. Wagner, J. G. (1971). Biopharmaceutics and pharmacokinetics (pp. 57–148). Org. Intelligence Publisher.
54. Srikanth, M. V., Sunil, S. A., Rao, N. S., Uhumwangho, M. U., & Ramana Murthy, K.
V. (2010). Ion exchange resins as controlled drug delivery carriers. Journal of Scientific Research, 2(3), 11–597.Ballard, B. E. (1978). Sustained and controlled release drug delivery system (pp. 76–106). Marcel Dekker Inc.