Volume : 12, Issue : 12, December- 2025
Title:
A REVIEW ON FORMULATION AND EVALUATION OF NEEM OIL SUPPOSITORIES
Authors :
Mrs varsha, Mekala Arathi, Mididoddigambhir Himasree, Mohammad Malik, Nagandla Vaishnavi, Nalla Divyanjali
Abstract :
Neem oil (Azadirachta indica) is becoming increasingly popular as a phytotherapeutic agent due to its antibacterial, anti-inflammatory, and immunomodulatory characteristics. In recent years, neem oil-based suppositories have emerged as a viable delivery system for treating a variety of anorectal and gynecological disorders. This study highlights current understanding of their formulation methodologies, modes of action, therapeutic applications, and safety considerations. Neem oil suppositories are effective against bacterial, fungal, and viral infections, thanks to bioactive components such as azadirachtin, nimbidin, and gedunin. Their anti-inflammatory properties promote tissue repair, and the mucosal route increases localized drug availability while minimizing systemic exposure. Despite promising preclinical results and traditional medicinal use, high-quality clinical evidence is limited. Standardization, stability, and dose adjustment remain challenging. More study is needed to evaluate efficacy, develop safety profiles, and investigate innovative formulation methods. Neem oil suppositories constitute an important field of research in natural product-based therapies.
Keywords: neem oil, Azadirachta indica, suppositories, phytotherapy, antimicrobial activity, anti-inflammatory agents, natural formulations, mucosal drug delivery, traditional medicine.
Cite This Article:
Please cite this article in press Mrs varsha et al., A Review On Formulation And Evaluation Of Neem Oil Suppositories, Indo Am. J. P. Sci, 2025; 12(12).
Number of Downloads : 10
References:
1. https://www.jrpsjournal.com/article.asp?issn=2322-1232;year=2019;volume=8;issue=2;spage=245;epage=252;aulast=Aremu
2. https://www.researchgate.net/publication/320272436_20_Neem_Oil
3. https://www.researchgate.net/publication/288971662_Review_on_neem_Azadirachta_indica_Thousand_problems_one_solution
4. https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1484766?scroll=top&needAccess=true
5. Naik MR, Bhattacharya A, Behera R, Agrawal D, Dehury S, Kumar S. Study of the anti-inflammatory effect of neem seed oil (Azadirachta indica) on infected albino rats. JHRR 2014; 1:66-9.
6. Jagadeesh K, Srinivas K, Revankar SP. Anti-inflammatory effect of Azadirachta indica (neem) in albino rats—An experimental study. IOSR J Pharm 2014; 4:34-8.
7. Akihisa T, Takahashi A, Kikuchi T, Takagi M, Watanabe K, Fukatsu M, et al. The melanogenesis-inhibitory, anti-inflammatory, and chemopreventive effects of limonoids in n-hexane extract of Azadirachta indica A. Juss. (neem) seeds. J Oleo Sci 2011; 60:53-9.
8. Kokate C, Purohit AP, Gokhale SB. Pharmacognosy. Maharashtra, India: Nirali Prakashan. 2010.
9. Sanjay L, Bandana R, Shantilata O. Anti-inflammatory activity of neem seed oil. Ind J pharmacol, 2000;33:303
10. https://www.ijarsct.co.in/Paper26836.pdf – Formulation and Evaluation of Herbal Suppositories (Neem and Turmeric)
11. https://pmc.ncbi.nlm.nih.gov/articles/PMC4791507/ – Therapeutics Role of Azadirachta indica (Neem) and Their Bioactive Compounds
12. https://ijpsr.com/bft-article/scope-for-harmonisation-of-herbal-medicine-regulations/ – IJPSR: Scope for Harmonisation of Herbal Medicine Regulations
13. https://brieflands.com/journals/jrps/articles/147388.pdf- Formulation and Evaluation of Neem (Azadirachta indica) Seed Oil Suppositories
14. https://www.pharmacognosyjournal.com/article/24/2-1-8-205.pdf – Pharmacognosy Journal: Review on Azadirachta Indica
15. https://ijpsr.com/bft-article/in-silico-studies-on-chemical-constituents-of-calotropis-species/ – IJPSR: In-Silico Studies on Chemical Constituents
16. https://www.ijpsjournal.com/assetsbackoffice/uploads/article/A+Comprehensive+Review+on+Neem+Seed+Oil+as+a+Natural+Contraceptive** – IJPS: Neem Seed Oil as Natural Contraceptive
17. https://www.phcogj.com/article/1046 – Pharmacognosy Journal: Azadirachta indica Antibacterial Activity
18. https://ijpsr.com/bft-article/herbal-remedies-a-new-era-for-psoriasis-diseases/ – IJPSR: Herbal Remedies for Psoriasis
19. https://patents.google.com/patent/WO2022172285A1/en – Neem Seed Oil Based Vaginal Capsule Patent
20. https://www.ijpsjournal.com/article/Formulation+and+Evaluation+of+Naproxen+Suppositories+for+Rectal+Drug+Delivery – IJPS: Formulation and Evaluation of Naproxen Suppositories
21. https://ijpsr.com/bft-article/recent-advancements-in-the-formulation-and-evaluation-of-microparticles-and-its-application/ – IJPSR: Recent Advancements in Microparticles Formulation
22. https://www.phytojournal.com – Pharmacognosy Journal Official Website
23. https://pmc.ncbi.nlm.nih.gov/articles/PMC6123880/ – Designing and Developing Suppository Formulations for Anti-inflammatory Agents
24. https://ijpsr.com/bft-article/formulation-and-in-vitro-evaluation-of-plga-nanoparticles-of-gefitinib/ – IJPSR: Formulation and Evaluation of PLGA Nanoparticles
25. https://www.florajournal.com – International Journal of Herbal Medicine
26. https://jptcp.com/index.php/jptcp/article/download/3792/3678/9840 – Design and Development of Lorazepam Rectal Suppositories
27. https://ijpsr.com/bft-article/formulation-evaluation-and-cytotoxic-potential-of-metronidazole-loaded-poloxamer-407-hydrogel-in-IJPSR:-Formulation-and-Evaluation-of-Metronidazole-Hydrogel
28. https://www.plantsjournal.com – Journal of Medicinal Plants Studies
29. https://archives.ijper.org/sites/default/files/IndJPhaEdRes_53_4s_580_0.pdf – Sustained Release Bioadhesive Suppository Formulation
30. https://ijpsr.com/?action=download_pdf&postid=75858 – IJPSR: Azadirachta indica Antioxidant and Antibacterial Properties
31. https://www.ijpsonline.com/articles/formulation-and-evaluation-of-tramadol-hydrochloride-rectal-suppositories.html – IJPS: Tramadol Hydrochloride Rectal Suppositories
32. https://ijpsr.com/?action=download_pdf&postid=112800 – IJPSR: Neem, Aloe Vera, and Turmeric in Herbal Formulations
33. https://www.phcogj.com/sites/default/files/PharmacognJ-13-4-988.pdf – Pharmacognosy Journal: Antibacterial Activity of Neem vs Calcium Hydroxide
34. https://www.ijpsonline.com/articles/formulation-and-evaluation-of-compressed-suppositories-of-indomethacin.pdf – IJPS: Compressed Suppositories of Indomethacin
35. http://www.ijpsr.info/docs/IJPSR14-05-04-006.pdf – IJPSR: Design and Characterization of Neem-loaded Liposomes
36. https://www.ijpsonline.com/articles/design-and-evaluation-of-sustained-release-suppositories-of-nimesulide.pdf – IJPS: Sustained Release Suppositories of Nimesulide
37. https://www.rjpbcs.com – Research Journal of Pharmaceutical, Biological and Chemical Sciences
38. https://pubmed.ncbi.nlm.nih.gov/40609030/ – Selected Indian Medicinal Plants Anti-Inflammatory Activity
39. https://journalijmpcr.com – International Journal of Medical and Pharmaceutical Case Reports
40. https://www.rjpbcs.com/pdf/2021_12(2)/%5B11%5D.pdf – RJPBCS: International Scientific Communications in Breast Cancer
41. https://nopr.niscpr.res.in/bitstream/123456789/9823/1/IJNPR%201(2)%20150-167.pdf – NISCPR: Anti-inflammatory Properties and Chemo-profiles of Plants
42. https://www.ijcmph.com – International Journal of Community Medicine and Public Health
43. https://www.rjpbcs.com/author.html – RJPBCS Author Guidelines and Information
44. https://nopr.niscpr.res.in/handle/123456789/50624 – NISCPR: Anti-inflammatory Effect of Traditional Herbal Formula
45. https://www.ijcmph.com/index.php/ijcmph/article/view/11130-IJCMPH: Medicine Package Inserts Readability
46. https://www.rjpbcs.com/archives.html – RJPBCS Archives
47. https://www.ijarsct.co.in/Paper25248.pdf – IJARSCT: Review on Formulation and Development
48. http://www.jppcm.org – Journal of Pharmacy Practice and Community Medicine
49. https://ijarsct.co.in/Paper7885.pdf – IJARSCT: Evaluation of Formulation Parameters
50. https://www.wjpmr.com/download/article/47052019/1559281503.pdf – World Journal of Pharmaceutical and Medical Research: Medicinal Uses of Neem
51. https://journaljpri.com/index.php/JPRI/article/view/7418 – Journal of Pharmaceutical Research International: Case-Based Learning in Pharmacy
52. https://ijarsct.co.in/Paper7918.pdf – IJARSCT: Formulation Development Principles
53. https://www.wjpr.net/public/index.php/abstract_show/20564 – World Journal of Pharmaceutical Research: Neem and Herbal Cream
54. https://ijppr.humanjournals.com – International Journal of Pharmacy and Pharmaceutical Research
55. https://ijarsct.co.in/Paper14225.pdf – IJARSCT: Evaluation of Various Formulations
56. https://ijpsr.com/bft-article/herbal-immunomodulators-formulation-and-evaluation-of-a-tablet-containing-indian-herbs/ – IJPSR: Herbal Immunomodulators Formulation
57. https://www.phcogj.com/sites/default/files/PJ-11-6s-218%20(1).pdf – Pharmacognosy Journal: Azadirachta indica Antibacterial Activity (Herrera-Calderon)
58. https://ijpsr.com/bft-article/present-scenario-of-hepatoprotective-potential-of-medicinal-plants-an-updated-review/ – IJPSR: Hepatoprotective Potential of Medicinal Plants
59. https://www.ijpsjournal.com/assetsbackoffice/uploads/article/document-20240225104150.pdf – IJPS: Deekshitha Reddy Suppository Formulation Study