Volume : 12, Issue : 12, December- 2025
Title:
FORMULATION AND EVALUATION OF MUCOADHESIVE MICROSPHERES OF GENTAMICIN
Authors :
Anjali Singh, B. K. Dubey, Deepak Kumar Basedia, Mukesh Kumar Patel, Sunil Kumar Saha, Anuj Kumar Asati
Abstract :
The evaluation of Gentamicin-loaded mucoadhesive microspheres reveals their promising potential for enhancing drug delivery. The study comprehensively assessed key parameters such as percentage yield, entrapment efficiency, stability in acidic conditions, flow properties, particle size, zeta potential, and drug release profiles over three months. Among the formulations, F3 demonstrated the highest yield (73.36%) and entrapment efficiency (72.23%), indicating effective retention of Gentamicin. Stability tests in 0.1N HCl showed that while F3 maintained a transmittance of 74.45% initially, it declined over time, highlighting the need for further optimization to improve long-term stability. The mean particle size of F3 was 225.65 nm, with a zeta potential of -35.65 mV, suggesting good stability and reduced aggregation risk. The flow properties indicated acceptable handling characteristics, and the cumulative drug release study confirmed that the microspheres provided sustained release (94.45% over 12 hours) compared to plain Gentamicin (86.65%). Although entrapment efficiency decreased over three months, the physical appearance remained stable, underscoring the formulation’s viability. These findings suggest that Gentamicin-loaded mucoadhesive microspheres could enhance therapeutic efficacy in treating infections, warranting further research on stability improvements and clinical applications.
Keywords: Gentamicin, mucoadhesive microspheres, drug delivery, stability, particle size.
Cite This Article:
Please cite this article in press Anjali Singh et al., Formulation And Evaluation Of Mucoadhesive Microspheres Of Gentamicin, Indo Am. J. P. Sci, 2025; 12(12).
Number of Downloads : 10
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