Volume : 12, Issue : 12, December- 2025
Title:
EVALUATION OF CNIDIUM MONNIERI HYDROALCOHOLIC EXTRACT AS A POTENTIAL ANTIULCER AGENT IN WISTAR RATS
Authors :
Anjali*, Arpit Shrivastava, Prateek Kumar Jain, Harshita Jain
Abstract :
Peptic ulcer disease remains a prevalent gastrointestinal disorder primarily associated with excessive gastric acid secretion, oxidative stress, and impaired mucosal defense mechanisms. The present study aimed to evaluate the anti-ulcer potential of the hydroalcoholic extract of Cnidium monnieri (HECM) using experimentally induced gastric ulcer models in Wistar rats. Preliminary phytochemical screening revealed the presence of flavonoids, tannins, saponins, coumarins, lignins, terpenoids, and amino acids, suggesting possible gastroprotective activity. Acute oral toxicity studies conducted according to OECD guideline 423 demonstrated that HECM was safe up to a dose of 2000 mg/kg, with no observable mortality or behavioral abnormalities. Anti-ulcer activity was assessed using indomethacin-induced and pylorus ligation–induced ulcer models. Oral pretreatment with HECM (200 and 400 mg/kg) significantly reduced ulcer index, gastric juice volume, free and total acidity, and lipid peroxidation levels, while markedly increasing gastric pH and reduced glutathione content, compared with ulcer control groups. The higher dose (400 mg/kg) exhibited more pronounced gastroprotection, comparable to the standard drug lansoprazole. Histopathological examination further confirmed the protective effect of HECM by showing reduced mucosal damage and improved gastric tissue architecture. The findings suggest that the anti-ulcer activity of Cnidium monnieri may be attributed to its antioxidant and antisecretory properties. Overall, the study supports the potential of Cnidium monnieri as a safe and effective herbal therapeutic agent for the management of gastric ulcers.
Keywords: Cnidium monnieri, Hydroalcoholic extract, Anti-ulcer activity, Indomethacin-induced ulcer, Pylorus ligation, Oxidative stress, Gastric acidity, Wistar rats.
Cite This Article:
Please cite this article in press Anjali et al., Evaluation Of Cnidium Monnieri Hydroalcoholic Extract As A Potential Antiulcer Agent In Wistar Rats, Indo Am. J. P. Sci, 2025; 12(12).
Number of Downloads : 10
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