Volume : 12, Issue : 12, December- 2025
Title:
SPHERICAL AGGLOMERATION TECHNIQUES IN PHARMACEUTICAL PARTICLE ENGINEERING A COMPREHENSIVE DEEP-DIVE REVIEW FOR MODERN SOLID DOSAGE FORM DEVELOPMENT
Authors :
P.Saranya*, CH.Bhargavi, G.Chandhini, M.RamiReddy, V. Nithin Reddy and V.Saikishore
Abstract :
The pharmaceutical industry is currently facing significant challenges in the development of solid dosage forms due to the increasing prevalence of poorly soluble, highly potent drug molecules. A substantial proportion of newly developed active pharmaceutical ingredients (APIs) fall under Biopharmaceutics Classification System (BCS) Class II, characterized by low aqueous solubility and high permeability. Conventional manufacturing techniques such as wet and dry granulation often fail to deliver the desired flowability, compressibility, and dissolution performance required for efficient tablet production and optimal bioavailability.Spherical agglomeration has emerged as a novel and efficient particle engineering technique that integrates crystallization, agglomeration, and granulation into a single step. By employing a carefully selected ternary solvent system consisting of a good solvent, poor solvent, and bridging liquid, this technique enables the formation of dense, spherical agglomerates with superior micromeritic properties. Advanced spherical agglomeration methods such as Quasi-Emulsion Solvent Diffusion (QESD), Ammonia Diffusion Method (ADM), and Neutralization techniques allow precise control over particle size, morphology, and mechanical strength.This article provides a comprehensive and technically detailed review of spherical agglomeration techniques, focusing on fundamental mechanisms, physicochemical principles, process methodologies, pharmaceutical applications, and industrial challenges. Special emphasis is placed on direct compression applications, bioavailability enhancement of hydrophobic drugs, and the integration of Quality by Design (QbD) concepts for industrial scalability. The review highlights spherical agglomeration as a paradigm-shifting approach in pharmaceutical particle engineering.
Keywords: Spherical Agglomeration, Particle Engineering, Quality by Design
Cite This Article:
Please cite this article in press P.Saranya et al., Spherical agglomeration techniques in pharmaceutical particle engineering A comprehensive deep-dive review for modern solid dosage form development , Indo Am. J. P. Sci, 2025; 12(12).
Number of Downloads : 10
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