Volume : 12, Issue : 12, December- 2025

Title:

FAST DISSOLVING ORAL FILMS AS A PATIENT-CENTRIC DRUG DELIVERY SYSTEM: A COMPREHENSIVE REVIEW

Authors :

Priyanka Ojha*, Dr. Satkar Prasad

Abstract :

Fast dissolving oral films (FDOFs) have emerged as a novel and patient-friendly drug delivery system designed to overcome the limitations associated with conventional oral dosage forms. These thin polymeric films rapidly disintegrate in the oral cavity without the need for water, providing ease of administration, improved patient compliance, and rapid onset of therapeutic action. FDOFs are particularly beneficial for pediatric, geriatric, and dysphagic patients, as well as in situations requiring immediate drug action. The formulation of fast dissolving films involves the careful selection of film-forming polymers, plasticizers, and taste-masking agents to achieve optimal mechanical strength, rapid disintegration, and acceptable palatability. Various manufacturing techniques, including solvent casting, hot-melt extrusion, and emerging technologies such as 3D printing, have been explored to enhance scalability and product quality. This review highlights the composition, manufacturing methods, evaluation parameters, advantages, applications, and recent research advancements in fast dissolving oral films, emphasizing their growing potential in modern pharmaceutical drug delivery.
Keywords: Fast dissolving oral films, Oral thin films, Patient compliance, Solvent casting, Rapid drug release, Buccal drug delivery.

Cite This Article:

Number of Downloads : 10

References:

1. Kanhed AA, Mahale AM, Bothra G, Rathod RS. Formulation and evaluation of fast dissolving oral films. JETIR. 2024;11(1):602–609.
2. Atneriya UK, Shah A, Joshi U, Solanki D. Pullulan-based mouth dissolving film of furosemide. Fabad J Pharm Sci. 2024;49(1):65–80.
3. Kumar A, Khandelwal M, Agrawal D, Goyal R. Oral dissolving film of lornoxicam. Int J Curr Pharm Rev Res. 2024;16(6):28–35.
4. Paul D, Ray P. Exploring the potential of fast dissolving oral films. Curr Trends Pharm Res. 2023;10(2):20–35.
5. Nadendla RR, Kanna S, Satyanarayana J, et al. Fast dissolving oral film of rivaroxaban. J Young Pharm. 2023;15(4):687–695.
6. Chavan PS, Maru AD, Khan MS. Mouth dissolving films of captopril. Res J Pharm Dosage Forms Technol. 2023;15(4):261–266.
7. Sajayan K, Swathy KK, Chandran SC, et al. Fast dissolving oral films of mefenamic acid. Indian J Pharm Educ Res. 2023;57(1s):41–51.
8. Nehete MA, Patil AP, Bhirud RR, Patil VR. Fast dissolving film of risperidone. World J Biol Pharm Health Sci. 2023;13(3):132–140.
9. Gharat SN, Bhongade YM, Sawkare AD. Optimization of rizatriptan fast dissolving film. Int J Pharm Sci Rev Res. 2023;82(2):40–47.
10. Sudhir M, Sruthi V, Reddy TV, et al. Oral fast dissolving film of hydralazine HCl. Curr Trends Biotechnol Pharm. 2022;16(2):171–178.
11. Agrawal YO, Husain M, Agnihotri VV, Goyal SN. Telmisartan mouth dissolving film. Food Hydrocoll Health. 2022;2:1–7.
12. Salawi A. Preparatory methods and characterization of orodispersible films. Pharmaceuticals. 2022;15:1–17.
13. Bhattacharyya S, Rangarao BG. Oral disintegrating film of fexofenadine HCl. Acta Pharm Sci. 2022;60(4):345–362.
14. Kurmi R, Ganju K, Lodhi DS, Chouksey K. Fast dissolving oral film of anti-migraine drug. WJPMR. 2022;8(1):150–160.
15. Elshafeey AH, El-Dahmy RM. Paroxetine nanosuspension loaded oral films. Pharmaceutics. 2021;13(11):1869.
16. Alkahtani ME, Aodah AH, Abu Asab OA, et al. Fast dissolving films of escitalopram/quetiapine. Pharmaceutics. 2021;13(6):891.
17. Bhatt P, Singh S, Sharma SK, Rabiu S. Fast dissolving buccal strip of frovatriptan. Int J Pharm Investig. 2021;11(1):69–75.
18. Mahaparale S, Wagh BS. Mouth dissolving film of glycopyrrolate. IJCRT. 2021;9(9):509–516.
19. Puttaswamy N. Fast dissolving oral film of ramipril. Int J Pharm Sci Drug Res. 2020;12:390–395.
20. Latif R, Ashfaq M. Fast dissolving oral films of alprazolam. J Adv Med Pharm Sci. 2019;21(4):1–20.
21. Solanki A, Gupta N, Jain S. Fast dissolving oral film of antipsychotic drug. J Drug Deliv Ther. 2019;9(4):181–185.
22. Wadetwar RN, Ali F, Kanojiya P. Fast dissolving sublingual film of paroxetine HCl. Asian J Pharm Clin Res. 2019;12(10):126–132.
23. Bala R, Pawar P, Khanna S, Arora S. Orally dissolving strips: A new approach. Int J Pharm Investig. 2013;3(2):67–76.
24. Panchal MS, Patel H, Bagada A, Vadalia KR. Mouth dissolving film of ropinirole HCl. IJPRAS. 2012;1(3):60–72.
25. Mahajan A, Chhabra N, Aggarwal G. Fast dissolving buccal films: A review. Der Pharm Lett. 2011;3(1):152–165.