Volume : 13, Issue : 01, January – 2026
Title:
A STUDY ON COMPARISON OF DISSOLUTION PROFILE STUDY OF IMMEDIATE-RELEASE DICLOFENAC SODIUM TABLETS
Authors :
Dola. Naresh
Abstract :
Background: Diclofenac sodium is a widely used pain-relieving medicine available in many branded and generic tablet forms. Although these products contain the same drug and dose, differences in formulation may affect drug release and therapeutic effectiveness. This study aimed to compare the pharmaceutical quality and in-vitro dissolution profiles of three commercially available immediate-release diclofenac sodium tablet brands.
Methods: Tablets were evaluated for physical parameters such as weight variation, hardness, friability, disintegration time, drug content (assay), and dissolution behavior using standard pharmacopeial methods. Dissolution profiles were compared using dissolution efficiency and similarity (f₂) and difference (f₁) factors.
Results: All brands complied with pharmacopeial limits for physical tests and assay (98–102%). More than 85% drug release was observed within 30 minutes for all brands. Similarity factor values indicated comparable dissolution profiles.
Conclusion: The studied diclofenac sodium tablet brands showed acceptable quality and similar dissolution behavior, suggesting therapeutic equivalence and interchangeability.
Cite This Article:
Please cite this article in press Dola. Naresh et al., A Study On Comparison Of Dissolution Profile Study Of Immediate-Release Diclofenac Sodium Tablets, Indo Am. J. P. Sci, 2025; 12(12).
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