Volume : 13, Issue : 01, January – 2026
Title:
FORMULATION AND IN-VITRO EVALUATION OF RIFAMPICIN NIOSOMAL DRUG DELIVERY SYSTEM
Authors :
Banavath Srikanth*, Dr Mohd Abdul Hadi
Abstract :
The present study focused on the formulation, characterization, and in-vitro evaluation of rifampicin-loaded niosomes as a novel drug delivery system aimed at improving solubility, stability, and sustained release of the drug. Preformulation studies revealed that rifampicin is a reddish-brown crystalline powder, tasteless, odorless, with a melting point of 183–188 °C, and is poorly soluble in water (~2 mg/mL) but freely soluble in organic solvents such as methanol, ethanol, and chloroform. Drug–excipient compatibility assessed by FT-IR indicated no chemical interactions. Niosomes were prepared using non-ionic surfactants and cholesterol, with optimization based on entrapment efficiency, particle size, and zeta potential. The prepared formulations exhibited entrapment efficiencies ranging from 76.35–83.59 %, with the optimized formulation (F7) showing 83.59 % EE. SEM analysis confirmed nearly spherical vesicles with rough surfaces, while dynamic light scattering revealed a mean particle size of 168 nm and a zeta potential of –25 mV, indicating good physical stability. In-vitro release studies conducted using the Franz diffusion cell demonstrated sustained release of rifampicin up to 8 hours, with the optimized formulation achieving 97.55 % cumulative drug release. Release kinetics fitted best to the zero-order model, suggesting a constant release rate, and the Higuchi model indicated a diffusion-controlled mechanism. Accelerated stability studies over three months at 40 ± 2 °C and 75 ± 5 % RH confirmed the stability of the formulation with negligible drug degradation. Overall, the study concluded that rifampicin niosomes provide a promising approach for enhanced solubility, sustained release, and stability, potentially improving therapeutic efficacy and patient compliance.
Keywords: Niosomes, FTIR Studies, In vitro drug release studies
Cite This Article:
Please cite this article in press Banavath Srikanth et al., Formulation And In-Vitro Evaluation Of Rifampicin Niosomal Drug Delivery System, Indo Am. J. P. Sci, 2026; 13(01).
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