Volume : 13, Issue : 01, January – 2026

Title:

PREPARATION AND IN VITRO EVALUATION OF DISULFIRAM LOZENGES

Authors :

Ms. Arifa Banu, Mohd Aftab Uddin, Saboor Arshi, Sania Naaz, Noorjaha Begum, Aaine Ashfaq

Abstract :

Disulfiram, an alcohol deterrent agent, has been reformulated as a medicated lozenge to enhance patient compliance and enable sustained drug delivery through the oral mucosa. This research focuses on the evaluation and preparation of disulfiram lozenges using the heat and congealing method, incorporating natural polymers such as microcrystalline cellulose and acacia in varying concentrations across five formulations (F1–F5). The aim was to identify a formulation that offers optimal hardness, friability, weight uniformity, and sustained drug release. Organoleptic, physicochemical, and dissolution profile assessments were conducted, and drug release kinetics were analyzed using multiple models. Among the formulations, F3, containing 50 mg of acacia, demonstrated superior performance with 98.75% drug release at 40 minutes and obey constant-rate model and Higuchi release kinetics, showing a diffusion- and erosion-based release mechanism. The study highlights F3 as a promising candidate for the effective, sustained oral delivery of disulfiram, offering a convenient, water-free alternative that bypasses first-pass metabolism and enhances bioavailability for the management of alcohol dependence.
Key Words: Lozenges, Disulfuram, Alcohol

Cite This Article:

Please cite this article in press Arifa Banu et al., Preparation And In Vitro Evaluation Of Disulfiram Lozenges, Indo Am. J. P. Sci, 2026; 13(01).

REFERENCES:

1. Chanda R, Nallaguntla L. Formulation and evaluation of medicated lozenges for sore throat. Asian J Pharm Clin Res. 2020 Oct;13(10):62–67
2. Kothawade NP, Katti SA. UV method development and validation for the estimation of disulfiram in marketed tablet preparation. Int J Res Pharm Chem. 2016;6(3):528–33.
3. Barth KS, Malcolm RJ. Disulfiram: an old therapeutic with new applications. CNS Neurol Disord Drug Targets. 2010;9(1):5–12.
4. Chick J, Gough K. Disulfiram treatment of alcoholism. Br J Psychiatry. 1992 Jan;161(1):84–9.
5. Suh JJ, Pettinati HM, Kampman KM, O’Brien CP. The status of disulfiram: a half century later. J Clin Psychopharmacol. 2006 Jun;26(3):290–302.
6. Mutschler J, Kiefer F. Mechanism of action of disulfiram and treatment optimization in prevention of recurrent alcoholism. Praxis (Bern). 2013 Mar;102(3):139–46.
7. Mutschler J, Grosshans M, et al. Current findings and mechanisms of action of disulfiram in the treatment of alcohol dependence. Pharmacopsychiatry. 2016 Jul;49(4):137–41.
8. Lu Y, Pan Q, et al. Leveraging disulfiram to treat cancer: mechanisms of action, delivery strategies, and treatment regimes. Biomaterials. 2022; 281:121335.
9. Pothu R, Yamsani MR. Lozenges formulation and evaluation: a review. Int J Adv Pharm Res. 2014 Apr;5(5):290–8.
10. Vijayasri Kadirvel, Mithulesh Thirupathi Vasuki et.al., “Formulation And Evaluation Of Medicated Lozenges Using Traditional Herbs To Treat Sore Throat Infection” Journal Of Food Processing And Preservation 7 July 2022
11. Kumar A, Mishra MK, Afeefa, Chandrashekar KS, Pai G, Pai V. Development and evaluation of polyherbal lozenges for cold and flu. Indian J Pharm Educ Res. 2019 Apr;53(2 Suppl): s159–163
12. Binu Anand, Elessey Abraham et.al., “Formulation And Evaluation Of Herbal Lozenges Containing Eucalyptus Oil And Coleus Aromaticus Oil” Research Article 9 January 2018
13. Maranda Stokes, Sara Abdijadid “Disulfiram” National Library Of Medicine October 24, 2022
14. Nash T, Rice WG: Efficacies of zinc-finger-active drugs against Giardia lamblia. Antimicrob Agents Chemother. 1998 Jun;42(6):1488-92. [Article]
15. Bouma MJ, Snowdon D, Fairlamb AH, Ackers JP: Activity of disulfiram (bis (diethyl thio carbamoyl) disulphide) and ditiocarb (diethyl dithio carbamate) against metronidazole-sensitive and -resistant Trichomonas vaginalis and Tritrichomonas fetus. J Antimicrob Chemother. 1998 Dec;42(6):817-20.[Article]
16. Gaval-Cruz M, Weinshenker D: Mechanisms of disulfiram-induced cocaine abstinence: anti-abuse and cocaine relapse. Mol Interv. 2009 Aug;9(4):175-87. doi: 10.1124/mi.9.4.6. [Article]
17. L. Qian, F.L. Cantrell, in Encyclopedia of Toxicology (Third Edition), 2014.
18. F. Lee Cantrell, in Encyclopedia of Toxicology (Second Edition), 2005.
19. R. Douglas Bruce, Gerald Friedland, in Sande’s HIV/AIDS Medicine,2012. Binu Anand, Elessey Abraham et.al., “Formulation And Evaluation Of Herbal Lozenges Containing Eucalyptus Oil And Coleus Aromaticus Oil” Research Article 9 January 2018.
20. Sevinc Kurbanoglu et.al., “Carbon-based nanostructure for electrochemical analysis of oral medicines, ScienceDirect, Radiation Oncology [ninth edition],2010.
21. Suchitra Pundir, Abhay Murarilal Verma et.al., review on lozenges, journal der pharmazie forschung.2014 2(1): 1-10. Mahesh Babasaheb Kolap, Pratiksha Kisan Omase et.al., review on lozenges, Research Journal of Pharmacology and Pharmacodynamics, ISSN 2321-58369 (online).
22. Sumitha Reddy M. and Tejasri Ragabhoina et.al., Lozenges Formulation and Evaluation: A Review, International Journal of Pharmaceutical Research and Applications- Volume 6, Issue 6, Nov-Dec 2021, pp. 678- 684.
23. Dr. Shrikant K. Tilloo and Dr. Bodhankar et al., Medicated Chewable Lozenges, International Journal of Recent Scientific Research Volume 10, Issue 04(G), PP.32071- 32076, April 2019
24. Umashankar M S, Dinesh S R et.al., Chewable lozenges formulations–A Review, International Journal of Pharmacy. 2016,7(4).
25. R M Mehta “dispensing pharmacy” Vallabh Prakashan Third edition 2008 page no: 132-135