Volume : 13, Issue : 02, February – 2026
Title:
FORMULATION AND EVALUATION OF AN ORAL FLOATING TABLET OF ALFUZOSIN HYDROCHLORIDE
Authors :
Kurakula Deepak*, T. Vijaya Kumari, Dr. D. Venkata Ramana.
Abstract :
The present study focuses on the formulation and evaluation of an oral floating drug delivery system of Alfuzosin Hydrochloride designed to enhance gastric residence time and improve bioavailability. Alfuzosin Hydrochloride, used in the management of benign prostatic hyperplasia, exhibits better absorption in the upper gastrointestinal tract, making it a suitable candidate for gastro-retentive delivery. Floating tablets were prepared using the direct compression method employing hydrophilic polymers such as HPMC and gas-generating agents like sodium bicarbonate to achieve buoyancy. The formulated tablets were evaluated for pre-compression parameters including bulk density, tapped density, angle of repose, Carr’s index, and Hausner ratio to ensure good flow properties. Post-compression evaluation included hardness, friability, thickness, weight variation, drug content uniformity, floating lag time, total floating duration, and in-vitro dissolution studies. The optimized formulation demonstrated acceptable physical characteristics, rapid floating lag time, prolonged buoyancy exceeding 12 hours, and controlled drug release behavior following near zero-order kinetics. Stability studies indicated that the formulation remained stable under accelerated conditions. The results suggest that the developed oral floating tablet system is a promising approach for sustained delivery of Alfuzosin Hydrochloride with enhanced therapeutic effectiveness.
Keywords: Alfuzosin Hydrochloride, Oral Floating Tablet, Gastro-retentive Drug Delivery System, Floating Lag Time, HPMC, Sustained Release.
Cite This Article:
Please cite this article in press Kurakula Deepak et al., Formulation And Evaluation Of An Oral Floating Tablet Of Alfuzosin Hydrochloride, Indo Am. J. P. Sci, 2026; 13(02).
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