Volume : 13, Issue : 02, February – 2026
Title:
FORMULATION AND EVALUATION OF PREGABALIN PULSATILE DRUG DELIVERY SYSTEM
Authors :
Dr. Rama Bobba, Narala Varsha *, l. Jyothi rani, k. Sudhamani, H. Ramana
Abstract :
The present research was undertaken to formulate and evaluate a pulsatile drug delivery system of Pregabalin with the objective of providing time-controlled drug release in synchronization with the circadian rhythm of neuropathic pain. Pregabalin, an antiepileptic and analgesic agent, requires controlled release to improve therapeutic efficacy, reduce side effects, and enhance patient compliance. In this study, various polymers were employed to develop core and coating layers that could modulate the lag time followed by a rapid release of the drug.
The prepared formulations were evaluated for pre-compression and post-compression parameters, which were found to be within pharmacopeial limits. In vitro drug release studies revealed that the optimized formulation provided a desirable lag phase, followed by a rapid and complete release of Pregabalin, thereby meeting the criteria for pulsatile delivery.
The results suggest that a pulsatile drug delivery system of Pregabalin offers a promising approach for chronotherapeutic management of neuropathic pain and related disorders, ensuring improved drug release behaviour, better patient compliance, and therapeutic effectiveness compared to conventional dosage forms.
Keywords: Pregabalin, Pulsatile Drug Delivery System
Cite This Article:
Please cite this article in press Narala Varsha et al., Formulation And Evaluation Of Pregabalin Pulsatile Drug Delivery System ., Indo Am. J. P. Sci, 2026; 13(02).
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