Volume : 13, Issue : 03, March – 2026
Title:
CLINICAL EVALUATION OF A MULTI-COMPONENT NUTRACEUTICAL FORMULATION IN WOMEN WITH POLYCYSTIC OVARY SYNDROME: A PROSPECTIVE OPEN-LABEL STUDY
Authors :
*Venkata Suresh.P, Shagufta Khan, Rama Rao.N, Grace Mishra
Abstract :
Background: Polycystic ovary syndrome (PCOS) is a complex endocrine–metabolic disorder characterized by hyperandrogenism, insulin resistance, ovarian dysfunction, and stress-axis dysregulation. Nutraceutical interventions targeting multiple metabolic and hormonal pathways have gained attention as complementary therapeutic strategies.
Objective: To evaluate the short-term safety and clinical effects of a multi-component nutraceutical formulation in women diagnosed with PCOS.
Methods: Forty women aged 18–35 years fulfilling Rotterdam 2003 criteria were enrolled. Participants received one tablet daily for 30 days. Primary outcomes included fasting blood glucose (FBG), antral follicle count (AFC), ovarian volume, and serum cortisol. Secondary outcomes included WHOQOL-BREF scores and global clinical assessment. Paired statistical analysis compared baseline and Day 30 values.
Results: Thirty-eight participants completed the study. Significant reductions were observed in FBG (104.53 ± 9.56 to 98.06 ± 5.05 mg/dL), ovarian volume, AFC, and serum cortisol (p < 0.05). Quality-of-life scores improved across all domains. No serious adverse events were reported.
Conclusion: Short-term supplementation was associated with improvements in metabolic parameters, ovarian morphology, stress biomarkers, and quality-of-life indicators. Controlled randomized trials are required to confirm these preliminary findings.
Keywords: Polycystic ovary syndrome, nutraceutical, ovarian morphology, cortisol, insulin resistance, quality of life.
Cite This Article:
Please cite this article in press Venkata Suresh.Pet al., Clinical Evaluation Of A Multi-Component Nutraceutical Formulation In Women With Polycystic Ovary Syndrome: A Prospective Open-Label Study., Indo Am. J. P. Sci, 2026; 13(03).
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DOI: https://doi.org/10.1111/1471-0528.14754.