Volume : 13, Issue : 03, March – 2026
Title:
ASSESSESNENT OF THE ANTIDIABETIC ACTIVITY OF STEM AND BARK EXTRACT OF EUPHORBIA THYMIFOLIA IN STRETZOTOCIN INDUCED DIABETIC RATS
Authors :
Chandrakanta Jena*, Dr Nikunj Kishor Mishra, Dr Tushar Ranjan Mohapatra.
Abstract:
Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Despite the availability of several antidiabetic drugs, their long-term use is often associated with adverse effects, prompting the search for safer and more effective alternatives from medicinal plants. Euphorbia thymifolia is traditionally used in folk medicine for the management of diabetes and other metabolic disorders. The present study was designed to evaluate the antidiabetic activity of stem and bark extracts of Euphorbia thymifolia in streptozotocin (STZ)-induced diabetic rats.
Diabetes was induced in Wistar albino rats by a single intraperitoneal injection of streptozotocin (50 mg/kg body weight). The diabetic rats were treated orally with methanolic extracts of stem and bark of Euphorbia thymifolia at selected doses for 21 days. Fasting blood glucose levels were measured at regular intervals, and biochemical parameters such as serum insulin, lipid profile, liver glycogen, and body weight were assessed. Histopathological examination of pancreatic tissue was also carried out to evaluate the protective effect of the extracts on β-cells. Glibenclamide was used as a standard antidiabetic drug for comparison.
Treatment with stem and bark extracts of Euphorbia thymifolia showed a significant reduction in fasting blood glucose levels and improvement in body weight compared to diabetic control rats. The extracts also exhibited favourable effects on lipid profile and liver glycogen content, along with partial regeneration of pancreatic β-cells. The results suggest that Euphorbia thymifolia possesses significant antidiabetic activity, which may be attributed to its phytochemical constituents.
Keywords: Euphorbia thymifolia, Oral Glucose Tolerance Test, antihyperglycemic, Glibenclamide, diabetes mellitus, phytomedicine.
Cite This Article:
Please cite this article in press Chandrakanta Jena et al., Assessesnent Of The Antidiabetic Activity Of Stem And Bark Extract Of Euphorbia Thymifolia In Stretzotocin Induced Diabetic Rats., Indo Am. J. P. Sci, 2026; 13(03).
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