Volume : 13, Issue : 04, April – 2026

Title:

MICRONEEDLE SYSTEMS FOR PAINLESS VACCINATION- REVIEW ARTICLE

Authors :

Y. Renuka, Rama Devi Korn*, M. Tarini, M. Jahnavi

Abstract :

Transdermal vaccination with biodegradable microneedles is an area that is growing swiftly. Painful microneedles are one of the major drawbacks for people when it comes to vaccination. This has, therefore, led to a major focus in biomedical research on the development of a method for pain-free vaccination using microneedles. Microneedles are an array of micron-sized needles that can be used for the efficient and pain-free transdermal delivery of vaccine agents. Moreover, microneedle-based vaccination holds many advantages over the intramuscular injections of vaccines. These advantages include higher immunogenicity because targeted skin deliveries in the epidermis and dermis, which have a high number of antigen-presenting cells like Langerhans cells and dendritic cells. Microneedle patches appear much like a Band-Aid. They also have other advantages, which include no cold chain necessary. And potentially could be used for self-administration. The major advantage of microneedle-based vaccination is the controlled release of antigens in various forms, namely solutions and suspensions. The microneedle-based patch for particulate vaccine holds a great promise because of the beneficial effects of particulate antigen and minimally invasive vaccine strategies. However, to make microneedle-based vaccines successfully translatable, various challenges and requirements, which include accurate dosage measurement, proper formulation, and sterility, need to be met. This review will help the audience become aware of the growing advancements in microneedle-based vaccine-delivery devices.
KEYWORDS: Needle phobia, vaccine, transdermal, skin, microneedles.

Cite This Article:

Please cite this article in press Rama Devi Korni et al., Microneedle Systems For Painless Vaccination- Review Article., Indo Am. J. P. Sci, 2026; 13(04).

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