Volume : 13, Issue : 04, April – 2026

Title:

FORMULATION AND EVALUATION OF GASTRORETENTIVE BEADS OF CIMETIDINE

Authors :

Akash Kumar, Shradha Shende, Dr. Vashali Rathi

Abstract :

The present work aimed to develop and evaluate a gastroretentive sustained release dosage form of Cimetidine to prolong gastric residence time, achieve controlled plasma levels, and improve bioavailability for effective management of peptic ulcer. Preformulation studies confirmed the physicochemical properties of Cimetidine, including its crystalline nature, solubility profile, melting point (142–144 °C), partition coefficient (0.4), and λmax at 224 nm. Drug–excipient compatibility studies revealed no interaction, ensuring stability of the formulation. Cimetidine-loaded gastroretentive beads were prepared using the ionotropic gelation method with sodium alginate (2–4%) and gas-generating agents. The formulations exhibited percentage yields between 68.82–89.91%, particle sizes ranging from 174–267 µm, entrapment efficiencies of 71.28–94.32%, and swelling indices of 2.7–4.1. Floating ability studies in 0.1 N HCl (pH 1.2) demonstrated buoyancy values of 68.72–89.23%, with floating lag times of 37–55 seconds and total floating times exceeding 10 hours. Among all formulations, GB-1 showed superior performance with high yield (89.91%), smaller particle size (174 µm), maximum entrapment efficiency (94.32%), swelling index (4.1), and buoyancy (89.23%). In-vitro drug release studies confirmed sustained release, with GB-1 selected for kinetic modeling. The release profile best fitted the Korsmeyer–Peppas model (R² = 0.985), indicating diffusion-controlled release with possible swelling and erosion mechanisms. Stability studies over 30 days at 4 °C, 25 °C, and 40 °C confirmed the robustness of GB-1 with no significant variation in drug release. Overall, the optimized gastroretentive beads of Cimetidine (GB-1) demonstrated excellent floating ability, high entrapment efficiency and sustained release behavior, establishing their potential as a promising dosage form for prolonged gastric retention and improved therapeutic efficacy in peptic ulcer treatment
Keywords: Cimetidine, Gastroretentive, Ulcer, Ionotropic gelation, Floating beads

Cite This Article:

Please cite this article in press Akash Kumar et al., Formulation And Evaluation Of Gastroretentive Beads Of Cimetidine, Indo Am. J. P. Sci, 2026; 13(04).

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