Volume : 13, Issue : 04, April – 2026
Title:
FORMULATION DEVELOPMENT AND EVALUATION OF MICROSPHERE GEL OF ACYCLOVIR USING ALOEVERA BASE
Authors :
Ankur Anand, Shradha Shende, Dr. Vashali Rathi
Abstract :
The present investigation aimed to develop and evaluate a novel microsphere-based gel formulation of acyclovir to enhance solubility, provide controlled release, and improve patient compliance. Preformulation studies confirmed the physicochemical properties of acyclovir, including its crystalline nature, solubility profile, melting point (257–259 °C), and λmax at 252 nm in phosphate buffer (pH 7.4). Compatibility with excipients was established through FT-IR analysis. Six microsphere formulations (M-1 to M-6) were prepared using the w/o emulsion solvent evaporation method with varying concentrations of hydroxypropyl methylcellulose (HPMC). Characterization revealed yields ranging from 77.28–92.31%, particle sizes between 227.45–309.38 µm, and encapsulation efficiencies of 86.83–96.29%. Among these formulation, M-3 demonstrated superior performance with high yield (92.31%), optimal particle size (227.45 µm), and maximum encapsulation efficiency (96.29%). Microspheres were incorporated into carbopol gel bases (GM-1 to GM-6) and evaluated for pH, spreadability, viscosity, and in-vitro release. The optimized gel formulation GM-3 exhibited sustained drug release of 94.39% over 24 hours, following Zero Order kinetics (R² = 0.986). Stability studies conducted at 4 °C, 25 °C, and 40 °C for 30 days confirmed the robustness of GM-3, with no significant variation in drug release. Overall, the study demonstrates that acyclovir-loaded microsphere gels offer a stable, effective, and patient-friendly drug delivery system with controlled release and enhanced therapeutic efficacy. The optimized formulation (GM-3) holds promise for clinical application in the management of viral infections, with potential for improved patient compliance and long-term stability
Keywords: Acyclovir, Microspheres, Gel, Controlled release, Encapsulation efficiency, Topical drug delivery
Cite This Article:
Please cite this article in press Ankur Anand et al., Formulation Development And Evaluation Of Microsphere Gel Of Acyclovir Using Aloevera Base, Indo Am. J. P. Sci, 2026; 13(04).
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