Volume : 13, Issue : 05, May – 2026

Title:

FORMULATION AND EVALUATION OF ANTI ACNE TONER CONTAINING LIQUORICE EXTRACT

Authors :

Pallavi S. Gore, Nandkishor B Deshmukh, Dr. Swati P Deshmukh

Abstract :

Acne vulgaris is a chronic inflammatory skin disorder affecting a larger populations especially adolescence. The use of herbal formulations has gained significant attention due to their safety effectiveness and minimal side effects. This study focuses on the formulation and evaluation of anti-acne containing liquorice (Glycyrrhzia galbra) extract. Liquorice possesses anti-inflammatory antimicrobial and skin brightening properties that are beneficial in acne management. The toner toner was formulated using suitable excipient such as humectants preservatives and solvents. Evaluation parameters including pH stability viscosity antimicrobial activity and skin irritation test were performed. The results indicated that the formulated toner exhibited good stability acceptable PhD for skin compatibility and significant antimicrobial activity against acne causing bacteria. Hence the developed herbal toner can be considered an effective and safe alternative for active treatment
Keywords: Anti-acne toner, Liquorice extract, Glycyrrhiza galbra, Herbal formulation, Acne vulgaris, Antimicrobial activity, Cosmetic formulation, Glycyrrhirin

Cite This Article:

Please cite this article in press Pallavi S Gore et al., Formulation and evaluation of Anti Acne Toner containing Liquorice extract, Indo Am. J. P. Sci, 2026; 13(05).

REFERENCES:

1. Draelos ZD. Astringents, Masks, and Ancillary Skin Care Products. In Textbook of
Cosmetic Dermatology, Baran R, Maibach HI, Eds.; CRCPress: Boca Raton, FL, USA,
2017; 5: 178–181.
2. Sowmya K.V., Darsika C.X., Grace F., Shanmuganathan S., “Formulation & Evaluation
of Poly-herbal Face wash gel”, World Journal of Pharmacy & Pharmaceutical sciences,
2015; 4(6): 585-588.
3. Damle, M. Glycyrrhiza glabra (Licorice) – a potent medicinal herb. Inter J Herbal Medi,
2014, 2(2), 132-136.
4. Gao, X.H.; Zhang, L.; Wei, H.; Chen, H.D. Efficacy and safety of innovative
cosmeceuticals. Clin. Dermatol. 2008, 26, 367–374.[CrossRef] [PubMed]
5. Hoang, H.T.; Moon, J.-Y.; Lee, Y.-C. Natural Antioxidants from Plant Extracts in
Skincare Cosmetics: Recent Applications,Challenges and Perspectives. Cosmetics 2021,
8, 106. [CrossRef]
6. method for extracting licorice root extract powder [Internet].2023 [cited 2025 May 10].
Available from: http://www.greenskybio.com/blog4/the-optimal-method- for-extracting
licorice-root-extract-powder.html.
7. Vaidyanathan R, Anand B: Importance of Chemistry in Direction of use Herbal Cosmetics
and Cosmeceuticals. Research journal of. Cleanse your face thoroughly with a mild
herbal face pharmacy and technology, 2017; 10(12): 4460-4462
8. Draelos ZD. Astringents, Masks, and Ancillary Skin Care Shake the herbal skin toner
bottle well before use Products. In Textbook of Cosmetic Dermatology, Baran R,
9. Moisten a cotton pad with the toner and gently apply it Maibach HI, Eds.; CRCPress:
Boca Raton, FL, USA, 2017; 5:178–181.
10. Kumar P, Lone JF, Gairola S. Comparative macroscopic and microscopic characterization
of raw herbal drugs of Abrus precatorius L. and Glycyrrhiza glabra L. Pharmacogn
Res.2021;14(1):100– 106.
11. Tian X., et al. Clinical efficacy and safety of glycyrrhizic acid preparation:
systemati.review and meta-analysis. BMJ Open. 2021.
12. Gomaa A.A., et al. Glycyrrhizin and boswellic acids — potential nutraceuticals for
COVID-19:clinical trial outcomes. Inflammopharmacology / Springer. 2022.
13. Mittal A., et al. Recent developments in the antiviral activity of glycyrrhizic acid and
derivatives:review & mechanistic insights. Nanobioletters / review (2024).
14. Ballin N.Z., et al. Glycyrrhizinic acid in licorice products on the Danish market content &
consumer exposure. Food Chemistry / regulatory study. 2023.
15. EFSA Scientific Opinion: Safety and efficacy of glycyrrhizic acid — European Food
Safety Authority (EFSA) review. 2015.
16. Nazari S., Rameshrad M., Hosseinzadeh H. Toxicological effects of Glycyrrhiza
glabranarrative/toxicology review. Phytotherapy Research. 2017.
17. Chen Y., et al. Glycyrrhetinic acid suppresses cytokine storm induced by influenza
infection in mice — preclinical study. (Journal: Immunology / Virology).
18. Liao W., Wang T., Lin Y., et al. Clinical reports on glycyrrhizic acid preparation (GAP) in
COVID-19 patients with liver injury: improved liver enzymes and inflammatory markers.
(2020– 2021 clinical series).
19. Zendejas-Hernandez U., et al. Nebulized glycyrrhizin/enoxolone inhalation: phase I/II
study evaluating IL-17A modulation in COVID-19 — clinical trial report. Frontiers in
Immunology / 2024.
20. NCT04487964 ClinicalTrials.gov: Complementary intervention for COVID19
(glycyrrhizin + boswellic acids) randomized clinical trial registration.
21. Bailly C., Vergoten G. Glycyrrhizin: An alternative drug for the treatment of COVID
infection and associated respiratory syndrome? Pharmacology & Therapeutics. 2020.
22. Li J., Wang X., et al. In silico ADMET and molecular docking searching for glycyrrhizin
and related compounds as SARS-CoV-2 inhibitors. arXiv / computational study. 2020.
23. Ullah R., et al. Licorice extract: pharmacological profile, antiviral & antimicrobial activity
review. Journal of Ethnopharmacology / review.(2020–2023).
24. Bahramsoltani R., Farzaei M.H., Farzaei F., Abdollahi M. Medicinal plants and their
constituents with antiviral and anti-inflammatory properties in respiratory disorders:
systematic review. Phytotherapy / review.
25. Ranasinghe P., et al. Herbal medicine and respiratory diseases: current evidence and future
prospects. Respiratory Medicine Review / 2020s.
26. Jeddi A., et al. The oral hydroalcoholic extract of licorice for treatment of COVID- 19:
clinical trial report (TUMS JPC). 2023.
27. Li J., et al. Glycyrrhizic acid preparations in liver disease and antiviral therapy: clinical
experiences & mechanistic review. Hepatology / review. (2020–2022).
28. Research on glycyrrhizin metabolites and mechanism of pseudoaldosteronism: multiple
papers (Japan/Kampo literature).
29. World Health Organization. WHO Monographs on Selected Medicinal Plants: licorice
(Glycyrrhiza spp.) monograph. (WHO technical report series).
30. CIR Expert Panel Final Report: Safety assessment of glycyrrhizic acid and derivatives
(cosmetic/safety review). 2008.
31. ResearchGate / Ji X., et al. A comprehensive review of licorice: preparation, chemical
composition, bioactivities and applications (2024 preprint / comprehensive review).
32. . Nazari R., Rameshrad M., Hosseinzadeh H. Further toxicology insights —reproductive
and developmental safety of glycyrrhizin: review. Toxicology Letters /review.
33. Ballin NZ, et al. Surveillance study of glycyrrhizic acid levels in licorice products (market
analysis, 2022–2023).
34. Ballin NZ, et al. Surveillance study of glycyrrhizic acid levels in licorice products(market
analysis, 2022–2023
35. Ullrich S., et al. Glycyrrhizin derivatives as broad-spectrum antivirals: structural inssight
Sun Y., et al. Extraction, physicochemical properties, bioactivities and application of
natural sweeteners: review (licorice included). Food Chemistry. 2024.
36. Clinical case reports: severe hypokalemia and arrhythmia associated with high licorice
intake — multiple case reports (2000–2023). (Good to cite specific case reports in the paper.
37. González-Minero, F.J.; Bravo-Díaz, L. The Use of Plants in Skin-Care Products,
Cosmetics and Fragrances: Past and Present.Cosmetics 2018, 5, 50. [CrossRef]