Volume : 13, Issue : 06, June – 2026
Title:
DEVELOPMENT AND IN-VITRO EVALUATION OF TERBINAFINE-LOADED TRANSFEROSOMAL GEL FOR DEEP DERMAL FUNGAL INFECTION
Authors :
S.Vikram, Dr. A Eswar Kumar*
Abstract :
The present study aimed to develop and evaluate a Terbinafine-loaded transferosomal gel for enhanced topical delivery in the treatment of deep dermal fungal infections. Transferosomes were prepared by the thin-film hydration method using soya lecithin, cholesterol, and Span 80 in varying concentrations. The prepared transferosomes were incorporated into Carbopol 934 gel base to obtain transferosomal gel formulations (F1–F8). Preformulation studies, including organoleptic evaluation, solubility analysis, melting point determination, UV spectrophotometric analysis, and FTIR studies, were carried out to confirm the identity and compatibility of the drug. Particle size analysis revealed vesicle sizes in the nanometric range (218–324 nm), with formulation F7 exhibiting the smallest particle size of 218 nm and highest entrapment efficiency of 79.86%. SEM studies confirmed spherical and smooth vesicles without aggregation. Zeta potential values ranged from -20 mV to -28 mV, indicating good physical stability of the transferosomes. The transferosomal gels showed acceptable pH, viscosity, and spread ability suitable for topical application. In vitro drug release studies demonstrated sustained release of Terbinafine over 12 hours, with formulation F7 showing maximum drug release of 97.86%. Drug release kinetic analysis indicated that the optimized formulation followed the Higuchi diffusion model with concentration-dependent release characteristics. Stability studies performed according to ICH guidelines confirmed that the optimized formulation remained stable for three months under different storage conditions without significant changes in drug release or physical appearance. The results concluded that Terbinafine-loaded transferosomal gel is a promising carrier system for enhanced topical delivery, improved permeation, sustained drug release, and effective treatment of deep dermal fungal infections.
Keywords: Soya lecithin, FTIR studies, Thin film hydration method, Transferosomes, Gel, In vitro drug release studies
Cite This Article:
Please cite this article in press S.Vikram et al., Development And In-Vitro Evaluation Of Terbinafine-Loaded Transferosomal Gel For Deep Dermal Fungal Infection.., Indo Am. J. P. Sci, 2026; 13(06).
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