Volume : 13, Issue : 06, June – 2026

Title:

EPIDRUGS FOR COGNITIVE DISORDERS: STATUS, CHALLENGES AND PROMISES

Authors :

Nitha Salim*, Ayyappan Anitha

Abstract :

Epigenetic regulation plays a crucial role in connecting genetic vulnerability and environmental factors in the development of cognitive disorders. Conditions such as autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), Alzheimer’s disease (AD), and Parkinson’s disease (PD) exhibit disrupted DNA methylation, histone modifications, and aberrant expression of non-coding RNAs, all of which have the potential to interfere with neuronal plasticity and cognitive functions. Since such epigenetic changes are reversible, they offer promising targets for therapy. Recent research has explored histone deacetylase inhibitors (HDACis), DNA methylation modulators, and nutritional cofactors such as folate and S-adenosylmethionine (SAM) to restore normal gene activity and improve neural health via modulation of epigenetic factors. The gut microbiome has also emerged as an important epigenetic factor, with microbiota-based treatments such as probiotics, prebiotics and microbiota transfer therapies showing potential benefits in ASD. However, challenges remain in achieving long-term effects, avoiding off-target impacts, and translating experimental success into clinical outcomes. Future progress will depend on integrating multi-omics data, advanced epigenetic mapping, and personalized medicine approaches. Understanding how epigenetic mechanisms shape brain function could eventually lead to innovative and effective treatments for cognitive disorders.
Keywords: Cognitive disorders; Epigenetics; Epidrugs; Gut microbiome; Precision medicine

Cite This Article:

Please cite this article in press Ayyappan Anitha et al., Epidrugs For Cognitive Disorders: Status, Challenges And Promises, Indo Am. J. P. Sci, 2026; 13(06).

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