Volume : 13, Issue : 07, July – 2026

Title:

EVALUATION OF ANTI ASTHMATIC ACTIVITY OF ETHANOLIC LEAF EXTRACT OF CHLERODENDRUM INERME

Authors :

Bandi Rajendar*, B Sathvika, H Anil, K Srivaishnavi, K Supriya

Abstract :

In this study, investigate the anti asthmatic activity of the ethanolic leaf extract of Chlerodendrum inerme animal models using Histamine induce broncho constriction method. In which Animals are placed in an aerosol chamber and exposed to histamine or serotonin. The time it takes for the animal to collapse (asphyxial convulsion) is recorded. Protective drugs delay the onset of collapse. Antihistaminic activity was studied in guinea pigs using histamine-induced bronchospasm where preconvulsive dyspnea was used as an end point following exposure to histamine aerosol. It was evaluated for antihistamine and bronchodilator activities and it administrated at the doses of 100 and 200 mg/kg body weight. A dose response curve for histamine + Chlerodendrum inerme is lower, when compared with histamine induced contraction(p<0.05) at moderate dose level. The Chlerodendrum inerme at at the dise of 200mg significantly prolonged the latent period of convulsions as compared to control following the exposure of histamine aerosol. The result of present study shows that Chlerodendrum inerme significantly protected the Guinea pigs against histamine-induced bronchospasm. Significant increase in between pre and post treatment time (**P<0.01). The present study reveals that the Chlerodendrum inerme can be more effective in the treatment of Bronchial asthma.
Keywords: Chlerodendrum inerme (LM), asthma, anti-histaminic activity, bronchodilator activity

Cite This Article:

Please cite this article in press Bandi Rajendar et al., Evaluation Of Anti Asthmatic Activity Of Ethanolic Leaf Extract Of Chlerodendrum Inerme, Indo Am. J. P. Sci, 2026; 13(07).

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