Volume : 11, Issue : 10, October – 2024
Title:
FORMULATION AND IN VITRO EVALUATION OF COPOLYMERIZED HYDROGEL BASED EMPAGLIFLOZIN MICROPARTICLES
Authors :
Afshan Sultana*, Sumer Singh, Niranjan Panda, M.S.Ansari
Abstract :
The aim of this work was to enhance the physical and chemical properties of natural polymers while simultaneously reducing production costs by graft copolymerization procedures involving the natural polymer guar gum and the synthetic polymer poly(acrylamide). The optimal hydrogel formulation was developed as microparticles, incorporating Empagliflozin and characterized by various criteria. A graft copolymer of guar gum-g-poly(acrylamide) was synthesized using a free radical polymerization method in a specifically built jacketed reaction vessel under a continuous flow of nitrogen. Ceric ammonium nitrate (CAN) was employed as the initiator for the reaction. The preparation conditions of microparticles were adjusted by evaluating the entrapment effectiveness percentage, particle size, swelling index under varying pH settings, and their release profiles. FTIR measurements support the development of grafted copolymers, whereas DSC experiments indicate a relatively enhanced heat stability of these copolymers. The pAAm-g-GG/sodium alginate microparticles exhibited a nearly spherical morphology, as demonstrated by the SEM analysis. The swelling index was shown to be highest for the formulation that contains more concentration of alginate in phosphate buffer at pH 6.8. The release of Empagliflozin was discovered to be regulated with increasing polyacrylamide and sodium alginate content in the microparticles, with a greater release noted in a pH 6.8 medium compared to pH 1.2. The in vitro kinetics of Empagliflozin release from the polymeric microparticle adhered to the zero-order kinetics model with mechanism of release as anomalous diffusion. Empagliflozin microparticles based on hydrogel were effectively synthesized with optimized batches of Guar gum-g-poly(acrylamide) and sodium alginate through free radical ionization methods. All characterization parameters met the acceptance standards.
Keywords: Empagliflozin, Microparticles, Hydrogel, Guar gum, Acrylamide, Sodium alginate
Cite This Article:
Please cite this article in press Afshan Sultana et al., Formulation And In Vitro Evaluation Of Copolymerized Hydrogel Based Empagliflozin Microparticles..,Indo Am. J. P. Sci, 2024; 11 (10).
Number of Downloads : 10
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