Volume : 13, Issue : 07, July – 2026
Title:
FORMULATION AND EVALUATION OF MULTIPLE EMULSION SYSTEM CONTAINING ECONAZOLE
Authors :
Vaibhav S. Sahare, Mohd Bilal Sufi, Mudabbirul Haque
Abstract :
The present study aimed to formulate and evaluate a water-in-oil-in-water (W/O/W) multiple emulsion containing Econazole nitrate for sustained topical antifungal drug delivery. Multiple emulsion systems were developed using a two-step emulsification technique with suitable surfactants, polymers, and oil-phase components to enhance drug entrapment, stability, and controlled release. Six formulations (F1–F6) were prepared and evaluated for appearance, pH, viscosity, globule size, drug content, entrapment efficiency, spreadability, extrudability, and in vitro drug release. All formulations exhibited satisfactory physicochemical properties and good emulsion stability. Increasing polymer concentration improved viscosity, entrapment efficiency, and sustained drug release while reducing globule size. Among the formulations, F6 demonstrated the highest drug entrapment (89.1%), drug content (99.2%), excellent stability, and prolonged drug release over 12 hours following Korsmeyer–Peppas kinetics. The optimized multiple emulsion system offers a promising approach for improving topical antifungal therapy by enhancing drug retention, reducing application frequency, and improving patient compliance.
Keywords: Econazole nitrate, Multiple emulsion, Water-in-oil-in-water (W/O/W), Topical drug delivery, Sustained drug release, Antifungal therapy, Entrapment efficiency, Controlled release, Emulsion stability, Topical formulation.
Cite This Article:
Please cite this article in press Vaibhav S. Sahare et al., Formulation And Evaluation Of Multiple Emulsion System Containing Econazole, Indo Am. J. P. Sci, 2026; 13(07).
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