Volume : 13, Issue : 07, July – 2026

Title:

DESIGN, SYNTHESIS, CHARACTERIZATION AND IN-VITROANTI-INFLAMMATORY EVALUATION OF NOVEL INDOLE DERIVATIVES.

Authors :

Rutuja S. Pattekar, Prachi.P. Kanawade

Abstract :

Since inflammation is a complicated biological reaction linked to a wide range of acute and chronic illnesses, there is an ongoing need to produce safer and more potent anti-inflammatory drugs. A unique heterocyclic scaffold, indole is well known for its vast range of biological actions, including strong anti-inflammatory potential. A number of novel indole derivatives were logically designed and synthesized in the current work using suitable synthetic techniques. Physicochemical and spectroscopic methods, such as melting point determination, Fourier Transform Infrared (FT-IR) spectroscopy, Nuclear Magnetic Resonance (^1H NMR and ^13C NMR) spectroscopy, and Mass Spectrometry (MS), were used to purify and characterize the synthesized compounds and confirm their chemical structures. Diclofenac sodium was used as the reference standard in conventional assays, such as suppression of protein denaturation and membrane stabilization techniques, to assess the synthesized derivatives’ in-vitro anti-inflammatory effectiveness. Several synthetic compounds showed promise anti-inflammatory activity, according to the biological evaluation, and some derivatives showed inhibition that was similar to that of the standard medication. The kind and location of substituents on the indole nucleus had a major impact on the anti-inflammatory efficacy, according to preliminary structure–activity relationship (SAR) research.
These new indole derivatives appear to be attractive lead compounds for the creation of novel anti-inflammatory drugs. To determine their therapeutic potential and improve their pharmacological profile, more in-vivo pharmacological research, toxicity evaluations, and molecular docking studies are necessary.
Keywords: Indole, anti-inflammatory, spectroscopy, therapeutic, Nuclear Magnetic Resonance.

Cite This Article:

Please cite this article in press Rutuja S. Pattekar et al., Design, Synthesis, Characterization And In-Vitroanti-Inflammatory Evaluation Of Novel Indole Derivatives, Indo Am. J. P. Sci, 2026; 13(07).

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