Volume : 13, Issue : 08, August – 2026
Title:
REVIEW ARTICLE: FUTURE ASPECTS OF COLON DRUG DELIVERY SYSTEM
Authors :
Mrs. D. Punitha*, Dr. J. JaslinEdward, Mrs. T. Jaghatha, Ahamed Yaseen. S., Dhanusha. D., Libin Prasanna. S., Sherin Mersha. S., Sajith. S.P
Abstract :
The colon serves as a site where drugs can be delivered either locally or systemically. Local delivery is used for the topical treatment of inflammatory bowel disease. However, for more effective treatment, drugs should be delivered directly into the colon, which helps in reducing the side effects that affect the whole body. This review focuses on comparing the main methods used for colon-specific drug delivery, known as CDDS. These methods include prodrugs, pH and time-dependent systems, and microbially triggered systems, which have had limited success and face certain challenges. In comparison, newer methods such as pressure-controlled colonic delivery capsules (CODEST) and osmotic-controlled drug delivery systems are more effective. These newer approaches are unique because they offer better site-specific drug delivery in the body and are more feasible to manufacture.
Cite This Article:
Please cite this article in press D. Punitha et al., Review Article: Future Aspects Of Colon Drug Delivery System.,, Indo Am. J. P. Sci, 2026; 13(08)
REFERENCES:
1. Das S, Deshmukh R, Jha A. Role of natural polymers in the development of multiparculate systems for colon drug targeting.Syst Rev Pharmacy 2010;1(1):79–85
2. Leuva VR, Patel BG, Chaudhary DJ, Patel JN, Modasiya MMK. Oral colon-specific drug delivery system. J Pharm Res. 2012;5(4):2293–7.
3. Kumar M, Ali A, Kaldhone P, Shirode A, Kadam VJ. Report on pharmaceutical approaches to colon targeted drug delivery systems. JPharm Res. 2010;3(3).
4. Philip AK, Philip B. Colon targeted drug delivery systems: a review on primary and novel
approaches. Oman Med J. 2010;25(2):79–87.
5. Pramod Kumar Biswal, Anant Kumar and Anupam Singh Bhadouriya. Design and evolution of colon specific drug delivery system. IJPCBS. 2013; 3:1: 150-167
6. Lachman L, Lieberman HA, Kanig JL: The theory and practice of industrial pharmacy. 3rd edition. Bombay, Varghese publishing house: Hind Rajasthan building; 1991. p. 293.
7. Antonin KH, Rak R, Beick PR, Schenker U, Hastewell J, Fox R: The absorption of human calcitonin from the transverse colon of man. Int J Pharm. 1996;130: 33-39.
8. Tozaki H, Komoike J, Tada C, Maruyama T, Terabe A, Suzuki T, Yamamoto A, Muranishi S: Chitosan capsules for colon specific drug delivery: Improvement of insulin absorption from the rat colon. J Pharm Sci 1997; 86(9): 1016-1021.
9. Van-den GM, Kinget R: Oral colon-specific drug delivery: a review. Drug Delivery 1995; 2: 81-93. 6. Rama Prasad Y, Krishnaiah Y, Satyanarayana S: In vitro evaluation of guar gumas a carrier for colon-specific drug delivery. J Controlled Release 1998; 51: 281-
287.
10. Patel A, Bhatt N, Patel KR, Patel NM, Patel MR. Colon targeted drug delivery system: a review system. Journal of pharmaceutical science and bioscientific research. 2011 Jul;1(1):37-49.
11. Van Den Mooter G, Kinget R. Oral colon-specific drug deliv ery: a review. Drug Deliv. 1995;2(2):81–93.
12. S. Hua Front. Pharmacal, 2020, 11, 496058
13. D. Chenthamara , S. Subramaniam , S. G. Ramakrishnan , S. Krishnaswamy , M. M. Essa , F. H. Lin and M. W. Qoronfleh , Biomater. Res., 2019, 23 , 1 —
29.
14. L. E. McCoubrey , A. Favaron , A. Awad , M. Orlu , S. Gaisford and A. W. Basit , J. Controlled Release, 2023, 353 , 1107 —1126
15. S. Zhao , Y. Zhao , X. Yang and T. Zhao , Food Res. Int., 2023, 173 , 113403