Volume : 13, Issue : 08, August – 2026
Title:
DEVELOPMENT AND IN-VITRO EVALUATION OF PULSATILE DRUG DELIVERY SYSTEM FOR GLICLAZIDE
Authors :
Tappeti Anjali , K. Sudhamani ,L .Jyothi Rani, H.Ramana
Abstract :
Gliclazide is a second generation sulphonylurea and is widely used for managing NIDDM. The drug has a short biologic life and the absorption in the gastrointestinal tract is site specific. Thus, Gliclazide is an ideal drug for pulsatile drug delivery. The present work is to develop and evaluation of pulsin cap technology by using polymers like Ethyl cellulose, HPMC. From the reproducible results obtained from the executed trails of core and pulsin cap it can be concluded that F12 of core tablet and C3F4 of press pulsincap formulation maintained lag phase upto 6hrs and brust release was at 7th hr and followed by maximum release at the end of 8th hr, so it is selected as optimized formulations for designing Pulsatile device. Therefore the study proved that pulsincap formulation of Gliclazide can be successfully used as a time dependent modified Chronopharmaceutical formulation.
Keywords: Gliclazide, Sodium starch glycolate, Lycoat, Crospovidone, Ethyl cellulose.
Cite This Article:
Please cite this article in press Tappeti Anjali et al., Development And In-Vitro Evaluation Of Pulsatile Drug Delivery System For Gliclazide.,, Indo Am. J. P. Sci, 2026; 13(08).
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