Volume : 13, Issue : 08, August – 2026

Title:

HEPATOPROTECTIVE ACTIVITY OF SALIX SUBSERRATA AGAINST PARACETAMOL INDUCED HEPATOTOXICITY IN RATS

Authors :

Boini shruthi *, Dr. R. Narasimha Rao, Dr. N. Raghunandhan

Abstract :

Liver diseases are a large public health problem in the world. Hence, herbal drugs have become increasingly popular and their use is widespread. The present study was carried out to hepatoprotective activity of ethanolic leaves extract of Salix subserrata on Paracetamol induced hepatotoxicity in albino rats.
The ethanolic extract of Salix subserrata leaves at a dose of 500 mg/kg were administered to albino rats per orally for five days. Hepatotoxicity was induced in albino rats by Paracetamol administration by subcutaneous on 2nd and 3rd day of treatment. The results of the rats treated with leaves and roots extract of Salix subserrata were compared with silymarin. Biochemical parameters such as serum SGPT, SGOT, ALP, ACP, direct bilirubin and total bilirubin were estimated to assess the liver functions by semi-autoanalyzer using standard biochemical kits.
It was found that ethanolic leaves extract at a dose of 500 mg/kg exhibited protective effect against hepatotoxicity in rats. The extract shows significant (p>0.01) reduction of SGPT, SGOT, ALP, ACP, Total and direct bilirubin levels compared to Paracetamol treated rats. The hepatoprotective activity was furthermore supported by histopathological studies of liver tissue. The study indicates that ethanolic extract of Salix subserrata exhibits potent hepatoprotective activity.
Keywords: Salix subserrata, leaves, Paracetamol and Hepatoprotective activity.

Cite This Article:

Please cite this article in press Boini Shruthi et al., Hepatoprotective activity of Salix subserrata against paracetamol induced hepatotoxicity in rats. Indo Am. J. P. Sci, 2026; 13(08).

REFERENCES:

1. Shanmugasundaram P, Venkataraman S (2006). Hepatoprotective and antioxidant effects of Hygrophila auriculata (K. Schum) Heine Acanthaceae root extract. Journal of Ethnopharmacology 104: 124-128.
2. Saleem TSM, Chetty CM, Ramkanth S, Rajan VST, Kumar KM, Gauthaman K (2010). Hepatoprotective herbs – a review. International Journal of Research in Pharmaceutical Sciences 1: 1-5.
3. Kaplowitz N, Tsukamoto H (1996). Oxidative stress and liver disease. Progress in Liver Diseases 14: 131-159.
4. Ajith TA, Hema U, Aswathy MS (2007). Zingiber officinale Roscoe prevents acetaminophen-induced acute hepatotoxicity by enhancing hepatic antioxidant status.
1. Food and Chemical Toxicology 45: 2267-2272.
5. Timbrell J (2001). Introduction to Toxicology. 3rd ed. Taylor and Francis, New York, pp. 57-71.
6. Kohen R, Nyska A (2002). Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicologic Pathology 30: 620-650.
7. Gupta AK, Misra N (2006). Hepatoprotective activity of aqueous ethanolic extract of Chamomile capitula in paracetamol intoxicated albino rats. American Journal of Pharmacology and Toxicology 1: 17-20.
8. Negi AS, Kumar JK, Luqman S, Shanker K, Gupta MM, Khanuja SPS (2008). Recent advances in plant hepatoprotectives: A chemical and biological profile of some important leads. Medicinal Research Reviews 28: 746-772.
9. Kohle C, Schwarz M, Bock KW (2008). Promotion of hepatocarcinogenesis in humans and animal models. Archives of Toxicology 82: 623-631.
10. Miyoshi H, Rust C, Roberts PJ, Burgart LJ, Gores GJ (1999). Hepatocyte apoptosis after bile duct ligation in the mouse involves Fas. Gastroenterology 117: 669-677.

Volume : 13, Issue : 08, August – 2026

Title:

EVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY OF SAPINDUS EMARGINATUS IN RATS

Authors :

Chinthala Jamima*, Dr.R.narasimha Rao, Dr.N. Raghunandhan

Abstract :

Obesity and hyperlipidemia have become major disorders predominantly causing prevailing cardiovascular diseases and ultimately death. The prolonged use of anti-obesity drugs and statins for reducing obesity and blood lipid levels is leading toward adverse effects of kidneys and muscles, specifically rhabdomyolysis. The objective of this study is to evaluate potential of seeds of Sapindus emarginatus against hyperlipidemia. In this model of Hyperlipidemia, 30 adult male wistar rats (200-250gms) were evenly divided into 5 groups in both groups. Group-1 and Group-2 served as untreated and model controls respectively, while Group-3, 4 and 5 were the treatments groups which were simultaneously treated with standard, 100 and 200 mg/kg extract respectively along with High Fat Diet. On last day, blood samples for biochemical parameters, were obtained under inhaled diether anaesthesia. The outcomes of this study were expressed as mean standard error and data were evaluated by using analysis of variance followed by multiple comparisons. Oral administration of 100 mg/ kg and 200mg/kg body weight of Methanolic extract residual fraction of Moringa oleifera. Leaves exhibited a significant reduction (P < 0.01) in serum lipid parameters such as triglycerides, total cholesterol, low density lipoprotein (LDL), very LDL and increase in high density lipoprotein in hyperlipidemic rats when compared with hyperlipidemic control in both models. Our results demonstrated that Methanolic extract fraction of Sesbania grandiflora. Possessed significant antihyperlipidemic activity.
Keywords: Sesbania grandiflora, Cholesterol, LDL, triglycerides and antihyperlipidemic activity.

Cite This Article:

Please cite this article in press Chinthala Jamimaet al., Evaluation of Antihyperlipidemic activity of Sapindus Emarginatus in rats,, Indo Am. J. P. Sci, 2026; 13(08).

REFERENCES:

1. Amit G, Vandana S, Sidharth M. HYPERLIPIDEMIA: An Updated Review. Inter J of Biopharma & Toxicol Res 2011;1:81-89.
2. Virchow RP, Thrombose IG. In Gesammelte Abhandlungen zur Wissenschaftlichen Medicin. Frankfurt-am-Main, Meidinger Sohn & Company 1856, S 458-564.
3. Ankur rohilla, Nidhi Dagar, Seema Rohilla, Amarjeet Dahiya, Ashok Kushnoor. HYPERLIPIDEMIA- a deadly pathological condition. Inter J Curr Pharma Res 2012;4:15-18
4. Ross R, Glomset JA. The pathogenesis of atherosclerosis. N Engl J Med 1976;295:369-77.
5. Grundy SM, Vega GL. Hypertriglyceridemia: causes and relation to coronary heart disease – Semin. Thromb. Hemost 1988;14:249-64.
6. Dargel R. Lipoproteins and the etiopathogenesis of atherosclerosis. Zentralbl Allg Pathol 1989; 135: 501-504.